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Article

Integrated Optical Mach-Zehnder Interferometer Based on Organic-Inorganic Hybrids for Photonics-on-a-Chip Biosensing Applications

1
Department of Physics and CICECO—Aveiro Institute of Materials, University of Aveiro, 3810–193 Aveiro, Portugal
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Instituto de Telecomunicações, University of Aveiro, 3810–193 Aveiro, Portugal
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Department of Electronics, Telecommunications and Informatics, University of Aveiro, 3810-193 Aveiro, Portugal
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Department of Biology and CESAM, University of Aveiro, 3810–193 Aveiro, Portugal
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Department of Chemistry and CESAM, University of Aveiro, 3810–193 Aveiro, Portugal
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Department of Electric and Computer Engineering and Instituto de Telecomunicações, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal
*
Authors to whom correspondence should be addressed.
Sensors 2018, 18(3), 840; https://doi.org/10.3390/s18030840
Received: 1 February 2018 / Revised: 26 February 2018 / Accepted: 8 March 2018 / Published: 12 March 2018
(This article belongs to the Special Issue Lab-on-a-Chip–From Point of Care to Precision Medicine)
The development of portable low-cost integrated optics-based biosensors for photonics-on-a-chip devices for real-time diagnosis are of great interest, offering significant advantages over current analytical methods. We report the fabrication and characterization of an optical sensor based on a Mach-Zehnder interferometer to monitor the growing concentration of bacteria in a liquid medium. The device pattern was imprinted on transparent self-patternable organic-inorganic di-ureasil hybrid films by direct UV-laser, reducing the complexity and cost production compared with lithographic techniques or three-dimensional (3D) patterning using femtosecond lasers. The sensor performance was evaluated using, as an illustrative example, E. coli cell growth in an aqueous medium. The measured sensitivity (2 × 10−4 RIU) and limit of detection (LOD = 2 × 10−4) are among the best values known for low-refractive index contrast sensors. Furthermore, the di-ureasil hybrid used to produce this biosensor has additional advantages, such as mechanical flexibility, thermal stability, and low insertion losses due to fiber-device refractive index mismatch (~1.49). Therefore, the proposed sensor constitutes a direct, compact, fast, and cost-effective solution for monitoring the concentration of lived-cells. View Full-Text
Keywords: photonic; integrated optics; sol-gel; biosensors; E. coli; organic-inorganic hybrid photonic; integrated optics; sol-gel; biosensors; E. coli; organic-inorganic hybrid
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MDPI and ACS Style

Bastos, A.R.; Vicente, C.M.S.; Oliveira-Silva, R.; Silva, N.J.O.; Tacão, M.; Costa, J.P.d.; Lima, M.; André, P.S.; Ferreira, R.A.S. Integrated Optical Mach-Zehnder Interferometer Based on Organic-Inorganic Hybrids for Photonics-on-a-Chip Biosensing Applications. Sensors 2018, 18, 840. https://doi.org/10.3390/s18030840

AMA Style

Bastos AR, Vicente CMS, Oliveira-Silva R, Silva NJO, Tacão M, Costa JPd, Lima M, André PS, Ferreira RAS. Integrated Optical Mach-Zehnder Interferometer Based on Organic-Inorganic Hybrids for Photonics-on-a-Chip Biosensing Applications. Sensors. 2018; 18(3):840. https://doi.org/10.3390/s18030840

Chicago/Turabian Style

Bastos, Ana R., Carlos M. S. Vicente, Rui Oliveira-Silva, Nuno J. O. Silva, Marta Tacão, João P. da Costa, Mário Lima, Paulo S. André, and Rute A. S. Ferreira. 2018. "Integrated Optical Mach-Zehnder Interferometer Based on Organic-Inorganic Hybrids for Photonics-on-a-Chip Biosensing Applications" Sensors 18, no. 3: 840. https://doi.org/10.3390/s18030840

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