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Sensors 2018, 18(12), 4281;

Cholinesterases and Engineered Mutants for the Detection of Organophosphorus Pesticide Residues

School of Chemical & Environmental Engineering, Wuhan Polytechnic University, Wuhan 430023, China
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, and International Joint Research Center for Intelligent Biosensor Technology and Health, and Chemical Biology Center, College of Chemistry, Central China Normal University, Wuhan 430079, China
Hubei Key Laboratory of Wudang Local Chinese Medicine Research, School of Pharmacy, Hubei University of Medicine, Shiyan 442000, China
These authors made equal contributions.
Authors to whom correspondence should be addressed.
Received: 8 November 2018 / Revised: 27 November 2018 / Accepted: 1 December 2018 / Published: 5 December 2018
(This article belongs to the Special Issue Colorimetric and Fluorescent Sensors 2018)
Full-Text   |   PDF [1386 KB, uploaded 5 December 2018]   |  


Nowadays, pesticide residues constitute an increasing public health concern. Cholinesterases, acetylcholinesterase, and butyrylcholinesterase, are reported to be involved in detoxification processes owing to their capability of scavenging organophosphates and carbamates. Thus, these enzymes are targeted for the discovery of sensors aiming at detecting pesticide residues. In recent years, cholinesterase-based biosensors have attracted more and more attention in the detection of pesticides. Herein, this review describes the recent progress on the engineering of cholinesterases and the development of the corresponding sensors that could be used for the detection of organophosphorus pesticide residues. View Full-Text
Keywords: cholinesterase; mutant; organophosphorus pesticides; sensor cholinesterase; mutant; organophosphorus pesticides; sensor

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Xu, Y.-L.; Li, F.-Y.; Ndikuryayo, F.; Yang, W.-C.; Wang, H.-M. Cholinesterases and Engineered Mutants for the Detection of Organophosphorus Pesticide Residues. Sensors 2018, 18, 4281.

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