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Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles

1
Key Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, China
2
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650224, China
3
School of Geographical Science and Tourism Management, Chuxiong Normal University, Chuxiong 675000, China
*
Authors to whom correspondence should be addressed.
Sensors 2018, 18(11), 3927; https://doi.org/10.3390/s18113927
Received: 22 October 2018 / Revised: 4 November 2018 / Accepted: 8 November 2018 / Published: 14 November 2018
(This article belongs to the Section Biosensors)
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Abstract

Supramolecular host-guest interaction and sensing between cationic pillar[5]arenes (CP5) and L-carnitine were developed by the competitive host-guest recognition for the first time. The fluorescence sensing platform was constructed by CP5 functionalized Au nanoparticles ([email protected]) as receptor and probe (rhodamine 123, R123), which shown high sensitivity and selectivity for L-carnitine detection. Due to the negative charge and molecular size properties of L-carnitine, it can be highly captured by the CP5 via electrostatic interactions and hydrophobic interactions. The host-guest mechanism between PP5 and L-carnitine was studied by 1H NMR and molecular docking, indicating that more affinity binding force of CP5 with L-carnitine. Therefore, a selective and sensitive fluorescent method was developed. It has a linear response of 0.1–2.0 and 2.0–25.0 μM and a detection limit of 0.067 μM (S/N = 3). The fluorescent sensing platform was also used to detect L-carnitine in human serum and milk samples, which provided potential applications for the detection of drugs abuse and had path for guarding a serious food safety issues. View Full-Text
Keywords: cationic pillar[5]arenes; host–guest recognition; Au nanoparticles; L-carnitine cationic pillar[5]arenes; host–guest recognition; Au nanoparticles; L-carnitine
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Tan, X.; Yang, Y.; Luo, S.; Zhang, Z.; Zeng, W.; Zhang, T.; Su, F.; Zhou, L. Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles. Sensors 2018, 18, 3927.

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