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Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles

Key Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, China
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650224, China
School of Geographical Science and Tourism Management, Chuxiong Normal University, Chuxiong 675000, China
Authors to whom correspondence should be addressed.
Sensors 2018, 18(11), 3927;
Received: 22 October 2018 / Revised: 4 November 2018 / Accepted: 8 November 2018 / Published: 14 November 2018
(This article belongs to the Section Biosensors)
PDF [3426 KB, uploaded 14 November 2018]
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Supramolecular host-guest interaction and sensing between cationic pillar[5]arenes (CP5) and L-carnitine were developed by the competitive host-guest recognition for the first time. The fluorescence sensing platform was constructed by CP5 functionalized Au nanoparticles ([email protected]) as receptor and probe (rhodamine 123, R123), which shown high sensitivity and selectivity for L-carnitine detection. Due to the negative charge and molecular size properties of L-carnitine, it can be highly captured by the CP5 via electrostatic interactions and hydrophobic interactions. The host-guest mechanism between PP5 and L-carnitine was studied by 1H NMR and molecular docking, indicating that more affinity binding force of CP5 with L-carnitine. Therefore, a selective and sensitive fluorescent method was developed. It has a linear response of 0.1–2.0 and 2.0–25.0 μM and a detection limit of 0.067 μM (S/N = 3). The fluorescent sensing platform was also used to detect L-carnitine in human serum and milk samples, which provided potential applications for the detection of drugs abuse and had path for guarding a serious food safety issues. View Full-Text
Keywords: cationic pillar[5]arenes; host–guest recognition; Au nanoparticles; L-carnitine cationic pillar[5]arenes; host–guest recognition; Au nanoparticles; L-carnitine

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Tan, X.; Yang, Y.; Luo, S.; Zhang, Z.; Zeng, W.; Zhang, T.; Su, F.; Zhou, L. Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles. Sensors 2018, 18, 3927.

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