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Sensors 2018, 18(11), 3788; https://doi.org/10.3390/s18113788

Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System

1
Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
2
Department of Physics, Tsinghua University, Beijing 100084, China
3
School of Medicine, Tsinghua University, Beijing 100084, China
4
Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China
5
Division of biomedical engineering, University of Glasgow, 89 Dumbarton Rd, Glasgow G12 8QQ, UK
These authors contributed equally to this work and should be considered co-first authors.
*
Authors to whom correspondence should be addressed.
Received: 5 October 2018 / Revised: 29 October 2018 / Accepted: 30 October 2018 / Published: 6 November 2018
(This article belongs to the Special Issue Optical Fiber Sensors 2018–2019)
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Abstract

We propose a self-referential fast detection scheme for a frequency domain weak measurement system for the detection of enantiomeric impurities in chiral molecules. In a transmissive weak measurement system, the optical rotation (OR) is used to modify the pre-selected polarization state and the post-selection polarization state. We obtained the sum and difference of the optical rotations produced by the sample and the standard by rotating the quarter wave plate in the system. Then, we estimate the ratio of chiral molecules to enantiomeric impurities using the ratio of the central wavelength shifts caused by the addition and subtraction states described above. In this paper, our system has an optical resolution of 1.88 × 10−5°. At the same time, we completed the detection of the ratio of the two substances in the mixture of L-proline and D-proline in different proportions, which proved that our system can quickly detect the content of enantiomeric impurities in chiral molecules. View Full-Text
Keywords: weak measurement; self-reference; common light path system; enantiomeric impurity content detection weak measurement; self-reference; common light path system; enantiomeric impurity content detection
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Xu, Y.; Shi, L.; Guan, T.; Zhong, S.; Zhou, X.; Li, D.; Guo, C.; Yang, Y.; Wang, X.; Li, Z.; He, Y.; Xie, L.; Gan, Z. Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System. Sensors 2018, 18, 3788.

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