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Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization
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Key Enabling Technologies for Point-of-Care Diagnostics

CNR NANOTEC, Institute of Nanotechnology, via Monteroni, 73100 Lecce, Italy
Azienda Ospedaliero-Universitaria di Parma, via Gramsci 14, 43126 Parma, Italy
STMicroelectronics S.r.l., via Olivetti 2, 20864 Agrate Brianza, Italy
STMicroelectronics S.r.l., via Monteroni, 73100 Lecce, Italy
National Institute of Gastroenterology, “S. De Bellis” Research Hospital, via Turi 27, 70013 Castellana Grotte, Italy
Department of Mathematics and Physics, University of Salento, via Monteroni, 73100 Lecce, Italy
Authors to whom correspondence should be addressed.
Sensors 2018, 18(11), 3607;
Received: 3 August 2018 / Revised: 1 October 2018 / Accepted: 16 October 2018 / Published: 24 October 2018
(This article belongs to the Special Issue Lab-on-a-Chip–From Point of Care to Precision Medicine)
A major trend in biomedical engineering is the development of reliable, self-contained point-of-care (POC) devices for diagnostics and in-field assays. The new generation of such platforms increasingly addresses the clinical and environmental needs. Moreover, they are becoming more and more integrated with everyday objects, such as smartphones, and their spread among unskilled common people, has the power to improve the quality of life, both in the developed world and in low-resource settings. The future success of these tools will depend on the integration of the relevant key enabling technologies on an industrial scale (microfluidics with microelectronics, highly sensitive detection methods and low-cost materials for easy-to-use tools). Here, recent advances and perspectives will be reviewed across the large spectrum of their applications. View Full-Text
Keywords: lab-on-chip; point-of-care; in vitro diagnostics; biosensors; microfluidics lab-on-chip; point-of-care; in vitro diagnostics; biosensors; microfluidics
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Primiceri, E.; Chiriacò, M.S.; Notarangelo, F.M.; Crocamo, A.; Ardissino, D.; Cereda, M.; Bramanti, A.P.; Bianchessi, M.A.; Giannelli, G.; Maruccio, G. Key Enabling Technologies for Point-of-Care Diagnostics. Sensors 2018, 18, 3607.

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