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Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization

1
CNR NANOTEC Institute of Nanotechnology, via Monteroni, 73100 Lecce, Italy
2
Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy
3
STMicroelectronics, Via Monteroni, I-73100 Lecce, Italy
4
Department of Mathematics and Physics, University of Salento, via Monteroni, 73100 Lecce, Italy
*
Author to whom correspondence should be addressed.
Sensors 2018, 18(10), 3175; https://doi.org/10.3390/s18103175
Received: 8 August 2018 / Revised: 5 September 2018 / Accepted: 16 September 2018 / Published: 20 September 2018
(This article belongs to the Special Issue Lab-on-a-Chip–From Point of Care to Precision Medicine)
Interest in extracellular vesicles and in particular microvesicles and exosomes, which are constitutively produced by cells, is on the rise for their huge potential as biomarkers in a high number of disorders and pathologies as they are considered as carriers of information among cells, as well as being responsible for the spreading of diseases. Current methods of analysis of microvesicles and exosomes do not fulfill the requirements for their in-depth investigation and the complete exploitation of their diagnostic and prognostic value. Lab-on-chip methods have the potential and capabilities to bridge this gap and the technology is mature enough to provide all the necessary steps for a completely automated analysis of extracellular vesicles in body fluids. In this paper we provide an overview of the biological role of extracellular vesicles, standard biochemical methods of analysis and their limits, and a survey of lab-on-chip methods that are able to meet the needs of a deeper exploitation of these biological entities to drive their use in common clinical practice. View Full-Text
Keywords: lab-on-chip; microfabrication; microfluidics; biosensors; extracellular vesicles; exosomes lab-on-chip; microfabrication; microfluidics; biosensors; extracellular vesicles; exosomes
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MDPI and ACS Style

Chiriacò, M.S.; Bianco, M.; Nigro, A.; Primiceri, E.; Ferrara, F.; Romano, A.; Quattrini, A.; Furlan, R.; Arima, V.; Maruccio, G. Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization. Sensors 2018, 18, 3175. https://doi.org/10.3390/s18103175

AMA Style

Chiriacò MS, Bianco M, Nigro A, Primiceri E, Ferrara F, Romano A, Quattrini A, Furlan R, Arima V, Maruccio G. Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization. Sensors. 2018; 18(10):3175. https://doi.org/10.3390/s18103175

Chicago/Turabian Style

Chiriacò, Maria S.; Bianco, Monica; Nigro, Annamaria; Primiceri, Elisabetta; Ferrara, Francesco; Romano, Alessandro; Quattrini, Angelo; Furlan, Roberto; Arima, Valentina; Maruccio, Giuseppe. 2018. "Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization" Sensors 18, no. 10: 3175. https://doi.org/10.3390/s18103175

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