Next Article in Journal
Resource Allocation in Wireless Powered IoT System: A Mean Field Stackelberg Game-Based Approach
Next Article in Special Issue
Key Enabling Technologies for Point-of-Care Diagnostics
Previous Article in Journal
Segmentation-Based Color Channel Registration for Disparity Estimation of Dual Color-Filtered Aperture Camera
Previous Article in Special Issue
A Review of Planar PIV Systems and Image Processing Tools for Lab-On-Chip Microfluidics
Open AccessReview

Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization

CNR NANOTEC Institute of Nanotechnology, via Monteroni, 73100 Lecce, Italy
Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy
STMicroelectronics, Via Monteroni, I-73100 Lecce, Italy
Department of Mathematics and Physics, University of Salento, via Monteroni, 73100 Lecce, Italy
Author to whom correspondence should be addressed.
Sensors 2018, 18(10), 3175;
Received: 8 August 2018 / Revised: 5 September 2018 / Accepted: 16 September 2018 / Published: 20 September 2018
(This article belongs to the Special Issue Lab-on-a-Chip–From Point of Care to Precision Medicine)
Interest in extracellular vesicles and in particular microvesicles and exosomes, which are constitutively produced by cells, is on the rise for their huge potential as biomarkers in a high number of disorders and pathologies as they are considered as carriers of information among cells, as well as being responsible for the spreading of diseases. Current methods of analysis of microvesicles and exosomes do not fulfill the requirements for their in-depth investigation and the complete exploitation of their diagnostic and prognostic value. Lab-on-chip methods have the potential and capabilities to bridge this gap and the technology is mature enough to provide all the necessary steps for a completely automated analysis of extracellular vesicles in body fluids. In this paper we provide an overview of the biological role of extracellular vesicles, standard biochemical methods of analysis and their limits, and a survey of lab-on-chip methods that are able to meet the needs of a deeper exploitation of these biological entities to drive their use in common clinical practice. View Full-Text
Keywords: lab-on-chip; microfabrication; microfluidics; biosensors; extracellular vesicles; exosomes lab-on-chip; microfabrication; microfluidics; biosensors; extracellular vesicles; exosomes
Show Figures

Figure 1

MDPI and ACS Style

Chiriacò, M.S.; Bianco, M.; Nigro, A.; Primiceri, E.; Ferrara, F.; Romano, A.; Quattrini, A.; Furlan, R.; Arima, V.; Maruccio, G. Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization. Sensors 2018, 18, 3175.

AMA Style

Chiriacò MS, Bianco M, Nigro A, Primiceri E, Ferrara F, Romano A, Quattrini A, Furlan R, Arima V, Maruccio G. Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization. Sensors. 2018; 18(10):3175.

Chicago/Turabian Style

Chiriacò, Maria S.; Bianco, Monica; Nigro, Annamaria; Primiceri, Elisabetta; Ferrara, Francesco; Romano, Alessandro; Quattrini, Angelo; Furlan, Roberto; Arima, Valentina; Maruccio, Giuseppe. 2018. "Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization" Sensors 18, no. 10: 3175.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop