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Sensors 2018, 18(1), 103;

Applications and Advances in Bioelectronic Noses for Odour Sensing

3,* and 1,2,6,*
Hazards Monitoring Bionano Research Center (HMBRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-Ro, Yuseong-Gu, Daejeon 34141, Korea
Department of Nanobiotechnology, Korea University of Science and Technology (UST), 217 Gajeong-Ro, Yuseong-Gu, Daejeon 34113, Korea
Department of Chemical and Biological Engineering, Korea University, 145 Anam-Ro, Sungbuk-Gu, Seoul 02841, Korea
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Yuseong-Gu, Daejeon 34141, Korea
Department of Pathobiology, College of Veterinary Medicine Nursing & Allied Health (CVMNAH), Tuskegee University, Tuskegee, AL 36088, USA
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 27 September 2017 / Revised: 22 November 2017 / Accepted: 25 November 2017 / Published: 1 January 2018
(This article belongs to the Special Issue Electronic Tongues and Electronic Noses)
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A bioelectronic nose, an intelligent chemical sensor array system coupled with bio-receptors to identify gases and vapours, resembles mammalian olfaction by which many vertebrates can sniff out volatile organic compounds (VOCs) sensitively and specifically even at very low concentrations. Olfaction is undertaken by the olfactory system, which detects odorants that are inhaled through the nose where they come into contact with the olfactory epithelium containing olfactory receptors (ORs). Because of its ability to mimic biological olfaction, a bio-inspired electronic nose has been used to detect a variety of important compounds in complex environments. Recently, biosensor systems have been introduced that combine nanoelectronic technology and olfactory receptors themselves as a source of capturing elements for biosensing. In this article, we will present the latest advances in bioelectronic nose technology mimicking the olfactory system, including biological recognition elements, emerging detection systems, production and immobilization of sensing elements on sensor surface, and applications of bioelectronic noses. Furthermore, current research trends and future challenges in this field will be discussed. View Full-Text
Keywords: bioelectronic nose; olfactory receptor; OR; odour analysis; biosensor bioelectronic nose; olfactory receptor; OR; odour analysis; biosensor

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Dung, T.T.; Oh, Y.; Choi, S.-J.; Kim, I.-D.; Oh, M.-K.; Kim, M. Applications and Advances in Bioelectronic Noses for Odour Sensing. Sensors 2018, 18, 103.

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