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Sensors 2017, 17(8), 1887;

Recent Advances in Electrospun Nanofiber Interfaces for Biosensing Devices

Université Lyon, CNRS, Université Claude Bernard Lyon 1, ENS de Lyon, Institute of Analytical Sciences, UMR 5280, 5 Rue la Doua, F-69100 Villeurbanne, France
Laboratoire des Interfaces et des Matériaux Avancés, Faculté des Sciences de Monastir, Avenue de l’Environnement, University of Monastir, Monastir 5019, Tunisia
Université Lyon, Université Claude Bernard Lyon 1, CNRS, Institut des Nanotechnologies de Lyon, UMR5270, Bâtiment Léon Brillouin, 6, rue Ada Byron, F-69622 Villeurbanne CEDEX, France
Author to whom correspondence should be addressed.
Received: 4 July 2017 / Revised: 11 August 2017 / Accepted: 13 August 2017 / Published: 16 August 2017
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in France 2016)
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Electrospinning has emerged as a very powerful method combining efficiency, versatility and low cost to elaborate scalable ordered and complex nanofibrous assemblies from a rich variety of polymers. Electrospun nanofibers have demonstrated high potential for a wide spectrum of applications, including drug delivery, tissue engineering, energy conversion and storage, or physical and chemical sensors. The number of works related to biosensing devices integrating electrospun nanofibers has also increased substantially over the last decade. This review provides an overview of the current research activities and new trends in the field. Retaining the bioreceptor functionality is one of the main challenges associated with the production of nanofiber-based biosensing interfaces. The bioreceptors can be immobilized using various strategies, depending on the physical and chemical characteristics of both bioreceptors and nanofiber scaffolds, and on their interfacial interactions. The production of nanobiocomposites constituted by carbon, metal oxide or polymer electrospun nanofibers integrating bioreceptors and conductive nanomaterials (e.g., carbon nanotubes, metal nanoparticles) has been one of the major trends in the last few years. The use of electrospun nanofibers in ELISA-type bioassays, lab-on-a-chip and paper-based point-of-care devices is also highly promising. After a short and general description of electrospinning process, the different strategies to produce electrospun nanofiber biosensing interfaces are discussed. View Full-Text
Keywords: electrospinning; biosensing devices; bioreceptor immobilization; carbon nanofibers; metal oxide nanofibers; polymer nanofibers; metal nanoparticles; carbon nanotubes electrospinning; biosensing devices; bioreceptor immobilization; carbon nanofibers; metal oxide nanofibers; polymer nanofibers; metal nanoparticles; carbon nanotubes

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Sapountzi, E.; Braiek, M.; Chateaux, J.-F.; Jaffrezic-Renault, N.; Lagarde, F. Recent Advances in Electrospun Nanofiber Interfaces for Biosensing Devices. Sensors 2017, 17, 1887.

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