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Sensors 2017, 17(8), 1810; https://doi.org/10.3390/s17081810

Design of a New Ultracompact Resonant Plasmonic Multi-Analyte Label-Free Biosensing Platform

Optoelectronic Laboratory, Politecnico di Bari, Via Orabona 4, 70125 Bari, Italy
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Received: 4 June 2017 / Revised: 13 July 2017 / Accepted: 3 August 2017 / Published: 6 August 2017
(This article belongs to the Section Biosensors)
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Abstract

In this paper, we report on the design of a bio-multisensing platform for the selective label-free detection of protein biomarkers, carried out through a 3D numerical algorithm. The platform includes a number of biosensors, each of them is based on a plasmonic nanocavity, consisting of a periodic metal structure to be deposited on a silicon oxide substrate. Light is strongly confined in a region with extremely small size (=1.57 μm2), to enhance the light-matter interaction. A surface sensitivity Ss = 1.8 nm/nm has been calculated together with a detection limit of 128 pg/mm2. Such performance, together with the extremely small footprint, allow the integration of several devices on a single chip to realize extremely compact lab-on-chip microsystems. In addition, each sensing element of the platform has a good chemical stability that is guaranteed by the selection of gold for its fabrication. View Full-Text
Keywords: biosensor; plasmonics; label-fee; Bragg grating biosensor; plasmonics; label-fee; Bragg grating
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Dell’Olio, F.; Conteduca, D.; De Palo, M.; Ciminelli, C. Design of a New Ultracompact Resonant Plasmonic Multi-Analyte Label-Free Biosensing Platform. Sensors 2017, 17, 1810.

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