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The Development of Indicator Cotton Swabs for the Detection of pH in Wounds

1
JOANNEUM RESEARCH Forschungsgesellschaft mbH-Materials, Franz-Pichler-Straße 30, A-8160 Weiz, Austria
2
Medical University of Graz, Center for Medical Research, Stiftingtalstraße 24, A-8010 Graz, Austria
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Green Chemistry Centre of Excellence, University of York, York YO10 5DD, UK
4
Department of Dermatology and Venereology, Medical University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: W. Rudolf Seitz
Sensors 2017, 17(6), 1365; https://doi.org/10.3390/s17061365
Received: 24 April 2017 / Revised: 1 June 2017 / Accepted: 1 June 2017 / Published: 12 June 2017
(This article belongs to the Section Chemical Sensors)
Indicator cotton swabs have been developed in order to enable faster, less expensive, and simpler information gathering of a wound status. Swabs are normally used for cleaning the wound, but here, they were covalently functionalized with indicator chemistry. Thus, they in principle enable simultaneous wound cleaning and wound pH detection. Using an indicator dye with a color change from yellow to red, combined with an inert dye of blue color, a traffic light color change from green to red is induced when pH increases. The indicator cotton swabs (ICSs) show a color change from green (appropriate wound pH) to red (elevated wound pH). This color change can be interpreted by the naked eye as well as by an optical color measurement device in order to obtain quantitative data based on the CIE L*a*b* color space. Two types of swabs have been developed—indicator cotton swabs ICS1 with a sensitive range from pH 5 to 7 and swabs ICS2 with a sensitive range from 6.5 to 8.5. The swabs are gamma-sterilized and the effect of sterilization on performance was found to be negligible. Furthermore, cytotoxicity testing shows cell viability and endotoxin levels to be within the allowable range. View Full-Text
Keywords: visual indicator; wound pH; pH indicator; sensor swabs; cotton swabs; traffic-light response visual indicator; wound pH; pH indicator; sensor swabs; cotton swabs; traffic-light response
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Schaude, C.; Fröhlich, E.; Meindl, C.; Attard, J.; Binder, B.; Mohr, G.J. The Development of Indicator Cotton Swabs for the Detection of pH in Wounds. Sensors 2017, 17, 1365.

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