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Sensors 2017, 17(6), 1235;

Study of ZnS Nanostructures Based Electrochemical and Photoelectrochemical Biosensors for Uric Acid Detection

State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an 710054, China
This paper is an extended version of our paper published in Zhao, Y.; Peng, N.; Wei, X.; Jiang, Z.; Kuo, W.C.H. Synthesis of ZnS urchin-like nanostructures for electrochemical determination of UA. In Proceedings of 2016 IEEE SENSORS, Orlando, FL, USA, 30 October–2 November 2016.
Author to whom correspondence should be addressed.
Academic Editor: Alexander Star
Received: 15 April 2017 / Revised: 14 May 2017 / Accepted: 18 May 2017 / Published: 28 May 2017
(This article belongs to the Section Biosensors)
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Uric acid (UA) is a kind of purine metabolism product and important in clinical diagnosis. In this work, we present a study of ZnS nanostructures-based electrochemical and photoelectrochemical biosensors for UA detection. Through a simple hydrothermal method and varying the ratio of reaction solvents, we obtained ZnS nanomaterials of one-dimensional to three-dimensional morphologies and they were characterized using field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD). To fabricate the UA biosensor and study the effect of material morphology on its performance, ZnS nanomaterials were deposited on indium tin oxide (ITO) conducting glass and then coated with uricase by physical absorption. Three kinds of working electrodes were characterized by cyclic voltammetry method. The effect of material morphology on performance of UA detection was investigated via amperometric response based electrochemical method based on enzymatic reaction. The ZnS urchin-like nanostructures electrode shows better sensitivity compared with those made of nanoparticles and nanoflakes because of its high surface-area-to-volume ratio. The photoelectrochemical method for detection of UA was also studied. The sensitivity was increased 5 times after irradiation of 300 nm UV light. These results indicate that ZnS nanostructures are good candidate materials for developing enzyme-based UA biosensors. View Full-Text
Keywords: biosensor; enzyme; nanostructures; ZnS; UA biosensor; enzyme; nanostructures; ZnS; UA

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Zhao, Y.; Wei, X.; Peng, N.; Wang, J.; Jiang, Z. Study of ZnS Nanostructures Based Electrochemical and Photoelectrochemical Biosensors for Uric Acid Detection. Sensors 2017, 17, 1235.

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