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Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor

Department of Medical Chemistry, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Rende, Tainan 71743, Taiwan
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Author to whom correspondence should be addressed.
Academic Editor: W. Rudolf Seitz
Sensors 2017, 17(2), 383; https://doi.org/10.3390/s17020383
Received: 28 December 2016 / Revised: 8 February 2017 / Accepted: 14 February 2017 / Published: 16 February 2017
(This article belongs to the Section Chemical Sensors)
A flow-electrolytic cell that consists of a bare gold wire or of different thiol-compound-modified gold electrodes (such as 2,4-thiazolidinedione, 2-mercapto-5-thiazoline, 2-mercaptothiazoline, l-cysteine, thioglycolic acid) was designed to be used in a voltammetric detector to identify l-selenomethionine and Se-methylseleno-l-cysteine using high-performance liquid chromatography. Both l-selenomethionine and Se-methylseleno-l-cysteine are more efficiently electrochemically oxidized on a thiol/gold than on a bare gold electrode. For the DC mode, and for measurements with suitable experimental parameters, a linear concentration from 10 to 1600 ng·mL−1 was found. The limits of quantification for l-selenomethionine and Se-methylseleno-l-cysteine were below 10 ng·mL−1. The method can be applied to the quantitative determination of l-selenomethionine and Se-methylseleno-l-cysteine in commercial selenium-containing supplement products. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable. View Full-Text
Keywords: thiol-modified gold electrodes; amperometric detection; l-selenomethionine; Se-methylseleno-l-cysteine thiol-modified gold electrodes; amperometric detection; l-selenomethionine; Se-methylseleno-l-cysteine
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Wang, L.-H.; Zhang, Y.-H. Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor. Sensors 2017, 17, 383.

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