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Open AccessArticle

A Lab-on-a-Chip-Based Non-Invasive Optical Sensor for Measuring Glucose in Saliva

by Dong Geon Jung 1,†, Daewoong Jung 2,† and Seong Ho Kong 1,*
Graduate School of Electronics Engineering, Kyungpook National University, Daegu 41566, Korea
Aircraft System Technology Group, Korea Institute of Industrial Technology (KITECH), Daegu 42994, Korea
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Sensors 2017, 17(11), 2607;
Received: 15 September 2017 / Revised: 8 November 2017 / Accepted: 10 November 2017 / Published: 13 November 2017
(This article belongs to the Special Issue Optical Biochemical Sensor Systems and Applications)
A lab-on-a-chip (LOC)-based non-invasive optical sensor for measuring glucose in saliva was fabricated. Existing glucose sensors utilizing blood require acquisition of a blood sample by pricking the finger, which is painful and inconvenient. To overcome these limitations, we propose a non-invasive glucose sensor with LOC, micro-electro-mechanical system and optical measurement technology. The proposed sensor for measuring glucose in saliva involves pretreatment, mixing, and measurement on a single tiny chip. Saliva containing glucose and glucose oxidase for glucose oxidation are injected through Inlets 1 and 2, respectively. Next, H2O2 is produced by the reaction between glucose and glucose oxidase in the pretreatment part. The saliva and generated H2O2 are mixed with a colorizing agent injected through Inlet 3 during the mixing part and the absorbance of the colorized mixture is measured in the measurement part. The absorbance of light increases as a function of glucose concentration at a wavelength of 630 nm. To measure the absorbance of the colorized saliva, a light-emitting diode with a wavelength of 630 nm and a photodiode were used during the measurement part. As a result, the measured output current of the photodiode decreased as glucose concentration in the saliva increased. View Full-Text
Keywords: glucose; optical sensor; saliva glucose; optical sensor; saliva
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Jung, D.G.; Jung, D.; Kong, S.H. A Lab-on-a-Chip-Based Non-Invasive Optical Sensor for Measuring Glucose in Saliva. Sensors 2017, 17, 2607.

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