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Open AccessArticle

A Lab-on-a-Chip-Based Non-Invasive Optical Sensor for Measuring Glucose in Saliva

by Dong Geon Jung 1,†, Daewoong Jung 2,† and Seong Ho Kong 1,*
1
Graduate School of Electronics Engineering, Kyungpook National University, Daegu 41566, Korea
2
Aircraft System Technology Group, Korea Institute of Industrial Technology (KITECH), Daegu 42994, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Sensors 2017, 17(11), 2607; https://doi.org/10.3390/s17112607
Received: 15 September 2017 / Revised: 8 November 2017 / Accepted: 10 November 2017 / Published: 13 November 2017
(This article belongs to the Special Issue Optical Biochemical Sensor Systems and Applications)
A lab-on-a-chip (LOC)-based non-invasive optical sensor for measuring glucose in saliva was fabricated. Existing glucose sensors utilizing blood require acquisition of a blood sample by pricking the finger, which is painful and inconvenient. To overcome these limitations, we propose a non-invasive glucose sensor with LOC, micro-electro-mechanical system and optical measurement technology. The proposed sensor for measuring glucose in saliva involves pretreatment, mixing, and measurement on a single tiny chip. Saliva containing glucose and glucose oxidase for glucose oxidation are injected through Inlets 1 and 2, respectively. Next, H2O2 is produced by the reaction between glucose and glucose oxidase in the pretreatment part. The saliva and generated H2O2 are mixed with a colorizing agent injected through Inlet 3 during the mixing part and the absorbance of the colorized mixture is measured in the measurement part. The absorbance of light increases as a function of glucose concentration at a wavelength of 630 nm. To measure the absorbance of the colorized saliva, a light-emitting diode with a wavelength of 630 nm and a photodiode were used during the measurement part. As a result, the measured output current of the photodiode decreased as glucose concentration in the saliva increased. View Full-Text
Keywords: glucose; optical sensor; saliva glucose; optical sensor; saliva
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Jung, D.G.; Jung, D.; Kong, S.H. A Lab-on-a-Chip-Based Non-Invasive Optical Sensor for Measuring Glucose in Saliva. Sensors 2017, 17, 2607.

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