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Sensors 2017, 17(10), 2388;

Time Multiplexed Active Neural Probe with 1356 Parallel Recording Sites

Imec, 3001 Leuven, Belgium
Electrical Engineering Department-ESAT, KU Leuven, 3001 Leuven, Belgium
Faculty of Psychology and Educational Sciences, KU Leuven, 3000 Leuven, Belgium
Neuro-electronics Research Flanders, 3001 Leuven, Belgium
VIB, 3000 Leuven, Belgium
Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H-1117 Budapest, Hungary
Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, H-1083 Budapest, Hungary
School of Engineering, University of Glasgow, Glasgow G10 8QQ, UK
Author to whom correspondence should be addressed.
Received: 11 August 2017 / Revised: 26 September 2017 / Accepted: 16 October 2017 / Published: 19 October 2017
(This article belongs to the Section Biosensors)
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We present a high electrode density and high channel count CMOS (complementary metal-oxide-semiconductor) active neural probe containing 1344 neuron sized recording pixels (20 µm × 20 µm) and 12 reference pixels (20 µm × 80 µm), densely packed on a 50 µm thick, 100 µm wide, and 8 mm long shank. The active electrodes or pixels consist of dedicated in-situ circuits for signal source amplification, which are directly located under each electrode. The probe supports the simultaneous recording of all 1356 electrodes with sufficient signal to noise ratio for typical neuroscience applications. For enhanced performance, further noise reduction can be achieved while using half of the electrodes (678). Both of these numbers considerably surpass the state-of-the art active neural probes in both electrode count and number of recording channels. The measured input referred noise in the action potential band is 12.4 µVrms, while using 678 electrodes, with just 3 µW power dissipation per pixel and 45 µW per read-out channel (including data transmission). View Full-Text
Keywords: active electrode; active neural probes; CMOS; high density component; neural amplifier; neural array; neural recording active electrode; active neural probes; CMOS; high density component; neural amplifier; neural array; neural recording

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Raducanu, B.C.; Yazicioglu, R.F.; Lopez, C.M.; Ballini, M.; Putzeys, J.; Wang, S.; Andrei, A.; Rochus, V.; Welkenhuysen, M.; Helleputte, N.; Musa, S.; Puers, R.; Kloosterman, F.; Hoof, C.; Fiáth, R.; Ulbert, I.; Mitra, S. Time Multiplexed Active Neural Probe with 1356 Parallel Recording Sites. Sensors 2017, 17, 2388.

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