Nanostructured Tip-Shaped Biosensors: Application of Six Sigma Approach for Enhanced Manufacturing
Abstract
:1. Introduction
2. Nanostructured Tip Bio-Sensors
2.1. Fabrication and Nanotip Shapes
2.2. Nanotip-Based Biosensors and Potential Challenges
2.3. Six Sigma Approach and Its Application to Nanomanufacturing
3. Materials and Methods
3.1. Application of the Six Sigma Approach to Nanotip Fabrication
- Define phase: The goal is to improve the yield of a dendritic nanotip.
- Measure phase: The production yield of a nanotip is 20%. The shape of a nanotip is not uniform.
- Analyze phase: The electric field for tip fabrication can be low, and the medium for carbon nanotubes can be degraded, which can lower the production yield of a nanotip.
- Improve phase: A higher electric field is applied, and the medium for carbon nanotube suspension is refreshed weekly.
- Control phase: When the factors of an electric field and carbon nanotube medium are controlled, the yield is improved from 20% to 80%. The uniform shape is improved.
3.2. Materials
3.3. Nanotip Fabrication
3.4. Nanotip Funtionalization
3.5. Sequence Specific DNA Detection
4. Results
4.1. Dendritic Nanotip Fabrication with Six Sigma Approach
4.2. Sequence Specific DNA Ddetection
5. Discussion
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Kahng, S.-J.; Kim, J.-H.; Chung, J.-H. Nanostructured Tip-Shaped Biosensors: Application of Six Sigma Approach for Enhanced Manufacturing. Sensors 2017, 17, 17. https://doi.org/10.3390/s17010017
Kahng S-J, Kim J-H, Chung J-H. Nanostructured Tip-Shaped Biosensors: Application of Six Sigma Approach for Enhanced Manufacturing. Sensors. 2017; 17(1):17. https://doi.org/10.3390/s17010017
Chicago/Turabian StyleKahng, Seong-Joong, Jong-Hoon Kim, and Jae-Hyun Chung. 2017. "Nanostructured Tip-Shaped Biosensors: Application of Six Sigma Approach for Enhanced Manufacturing" Sensors 17, no. 1: 17. https://doi.org/10.3390/s17010017