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Sensors 2016, 16(12), 2045;

Recent Progress in Electrochemical Biosensors for Glycoproteins

Graduate School of Engineering and Science, Akita University, 1-1 Tegatagaluenn-machi, Akita 010-8502, Japan
Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramakim, Sendai 980-8578, Japan
Author to whom correspondence should be addressed.
Academic Editor: Igor Medintz
Received: 5 October 2016 / Revised: 22 November 2016 / Accepted: 29 November 2016 / Published: 1 December 2016
(This article belongs to the Special Issue Sensors for Glycoproteins and Glycated Proteins)
Full-Text   |   PDF [3051 KB, uploaded 1 December 2016]   |  


This review provides an overview of recent progress in the development of electrochemical biosensors for glycoproteins. Electrochemical glycoprotein sensors are constructed by combining metal and carbon electrodes with glycoprotein-selective binding elements including antibodies, lectin, phenylboronic acid and molecularly imprinted polymers. A recent trend in the preparation of glycoprotein sensors is the successful use of nanomaterials such as graphene, carbon nanotube, and metal nanoparticles. These nanomaterials are extremely useful for improving the sensitivity of glycoprotein sensors. This review focuses mainly on the protocols for the preparation of glycoprotein sensors and the materials used. Recent improvements in glycoprotein sensors are discussed by grouping the sensors into several categories based on the materials used as recognition elements. View Full-Text
Keywords: biosensor; electrochemical sensor; glycoprotein; immunosensor; lectin; phenylboronic acid; molecularly imprinted polymers biosensor; electrochemical sensor; glycoprotein; immunosensor; lectin; phenylboronic acid; molecularly imprinted polymers

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Akiba, U.; Anzai, J.-I. Recent Progress in Electrochemical Biosensors for Glycoproteins. Sensors 2016, 16, 2045.

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