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Interferometric Reflectance Imaging Sensor (IRIS)—A Platform Technology for Multiplexed Diagnostics and Digital Detection
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Enhanced Vibrational Spectroscopies as Tools for Small Molecule Biosensing

UPMC Univ Paris 6, UMR CNRS 7197, Laboratoire de Réactivité de Surface, 4 Place Jussieu, F-75005 Paris, France
CNRS, UMR 7197, Laboratoire de Réactivité de Surface, F-75005 Paris, France
Center for Biomimetic Sensor Science, 50 Nanyang Drive, Singapore 637553, Singapore
Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS, (UMR 7244), 74 rue Marcel Cachin, F-93017 Bobigny, France
AIT Austrian Institute of Technology, Donau City Strasse 1, A-1220 Vienna, Austria
Author to whom correspondence should be addressed.
Academic Editors: M. Selim Ünlü and Ayca Yalcin Ozkumur
Sensors 2015, 15(9), 21239-21264;
Received: 15 March 2015 / Revised: 6 August 2015 / Accepted: 10 August 2015 / Published: 28 August 2015
(This article belongs to the Special Issue Advances in Optical Biosensors)
In this short summary we summarize some of the latest developments in vibrational spectroscopic tools applied for the sensing of (small) molecules and biomolecules in a label-free mode of operation. We first introduce various concepts for the enhancement of InfraRed spectroscopic techniques, including the principles of Attenuated Total Reflection InfraRed (ATR-IR), (phase-modulated) InfraRed Reflection Absorption Spectroscopy (IRRAS/PM-IRRAS), and Surface Enhanced Infrared Reflection Absorption Spectroscopy (SEIRAS). Particular attention is put on the use of novel nanostructured substrates that allow for the excitation of propagating and localized surface plasmon modes aimed at operating additional enhancement mechanisms. This is then be complemented by the description of the latest development in Surface- and Tip-Enhanced Raman Spectroscopies, again with an emphasis on the detection of small molecules or bioanalytes. View Full-Text
Keywords: biosensors; infrared; plasmonic; enhanced spectroscopies; SERS; IRRAS biosensors; infrared; plasmonic; enhanced spectroscopies; SERS; IRRAS
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Boujday, S.; Chapelle, M.L.; Srajer, J.; Knoll, W. Enhanced Vibrational Spectroscopies as Tools for Small Molecule Biosensing. Sensors 2015, 15, 21239-21264.

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