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Sensors 2015, 15(8), 17963-17976;

Towards Semi-Automatic Artifact Rejection for the Improvement of Alzheimer’s Disease Screening from EEG Signals

Data and Signal Processing Research Group, University of Vic–Central University of Catalonia, Vic, 08500 Barcelona, Spain
BCI Team, Brain Plasticity Laboratory, UMR 8249, CNRS, Paris 75005, France
ESPCI ParisTech, PSL Research University, Paris 75005, France
Author to whom correspondence should be addressed.
Academic Editor: Alexander Star
Received: 12 February 2015 / Revised: 2 July 2015 / Accepted: 14 July 2015 / Published: 23 July 2015
(This article belongs to the Section Biosensors)
Full-Text   |   PDF [897 KB, uploaded 23 July 2015]   |  


A large number of studies have analyzed measurable changes that Alzheimer’s disease causes on electroencephalography (EEG). Despite being easily reproducible, those markers have limited sensitivity, which reduces the interest of EEG as a screening tool for this pathology. This is for a large part due to the poor signal-to-noise ratio of EEG signals: EEG recordings are indeed usually corrupted by spurious extra-cerebral artifacts. These artifacts are responsible for a consequent degradation of the signal quality. We investigate the possibility to automatically clean a database of EEG recordings taken from patients suffering from Alzheimer’s disease and healthy age-matched controls. We present here an investigation of commonly used markers of EEG artifacts: kurtosis, sample entropy, zero-crossing rate and fractal dimension. We investigate the reliability of the markers, by comparison with human labeling of sources. Our results show significant differences with the sample entropy marker. We present a strategy for semi-automatic cleaning based on blind source separation, which may improve the specificity of Alzheimer screening using EEG signals. View Full-Text
Keywords: EEG; artifacts; blind source separation; Alzheimer’s disease; screening EEG; artifacts; blind source separation; Alzheimer’s disease; screening

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Solé-Casals, J.; Vialatte, F.-B. Towards Semi-Automatic Artifact Rejection for the Improvement of Alzheimer’s Disease Screening from EEG Signals. Sensors 2015, 15, 17963-17976.

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