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Sensors 2015, 15(12), 30011-30031;

Microfluidics Integrated Biosensors: A Leading Technology towards Lab-on-a-Chip and Sensing Applications

School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada
Nano-Biosensors Laboratory, Department of Biosystems and Agricultural Engineering, Michigan State University, 524 S. Shaw Lane, Room 115, East Lansing, MI 48224, USA
Carleton University, Department of Chemistry and Institute of Biochemistry, 225 Steacie Building 1125 Colonel By Drive Ottawa, ON K1S 5B6, Canada
Department of Health Sciences, College of Arts and Sciences, Qatar University, 2713 Doha, Qatar
Biomedical Research Center, Qatar University, 2713 Doha, Qatar
Author to whom correspondence should be addressed.
Academic Editors: Alexander Star and Frances S. Ligler
Received: 22 May 2015 / Revised: 16 September 2015 / Accepted: 2 November 2015 / Published: 1 December 2015
(This article belongs to the Section Biosensors)
Full-Text   |   PDF [3390 KB, uploaded 1 December 2015]   |  


A biosensor can be defined as a compact analytical device or unit incorporating a biological or biologically derived sensitive recognition element immobilized on a physicochemical transducer to measure one or more analytes. Microfluidic systems, on the other hand, provide throughput processing, enhance transport for controlling the flow conditions, increase the mixing rate of different reagents, reduce sample and reagents volume (down to nanoliter), increase sensitivity of detection, and utilize the same platform for both sample preparation and detection. In view of these advantages, the integration of microfluidic and biosensor technologies provides the ability to merge chemical and biological components into a single platform and offers new opportunities for future biosensing applications including portability, disposability, real-time detection, unprecedented accuracies, and simultaneous analysis of different analytes in a single device. This review aims at representing advances and achievements in the field of microfluidic-based biosensing. The review also presents examples extracted from the literature to demonstrate the advantages of merging microfluidic and biosensing technologies and illustrate the versatility that such integration promises in the future biosensing for emerging areas of biological engineering, biomedical studies, point-of-care diagnostics, environmental monitoring, and precision agriculture. View Full-Text
Keywords: microfluidic; biosensor; lab-on-a-chip; microfluidic-based biosensor; micro total analysis systems (μTAS) microfluidic; biosensor; lab-on-a-chip; microfluidic-based biosensor; micro total analysis systems (μTAS)

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Luka, G.; Ahmadi, A.; Najjaran, H.; Alocilja, E.; DeRosa, M.; Wolthers, K.; Malki, A.; Aziz, H.; Althani, A.; Hoorfar, M. Microfluidics Integrated Biosensors: A Leading Technology towards Lab-on-a-Chip and Sensing Applications. Sensors 2015, 15, 30011-30031.

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