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Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

International Clinical Research Center (ICRC), Integrated Center of Cellular Therapy and Regenerative Medicine (ICCT), St. Anne’s University Hospital, Brno 656 91, Czech Republic
Center for Biomedical Research, University of Algarve, Faro 8005-139, Portugal
Tissue Engineering Unit, Università Campus Bio-Medico di Roma, Rome 00128, Italy
Department of Biomaterials Science, University of Turku, Turku 20014, Finland
Authors to whom correspondence should be addressed.
Academic Editor: Sandeep Kumar Vashist
Sensors 2015, 15(12), 31142-31170;
Received: 22 September 2015 / Revised: 16 November 2015 / Accepted: 4 December 2015 / Published: 10 December 2015
(This article belongs to the Special Issue Novel Biomaterials and Sensors for Tissue Engineering)
PDF [549 KB, uploaded 10 December 2015]


Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called “organ-on-a-chip” technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field. View Full-Text
Keywords: microfluidics; BioMEMs; organ-on-a-chip; body-on-a-chip; tissue engineering microfluidics; BioMEMs; organ-on-a-chip; body-on-a-chip; tissue engineering

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Perestrelo, A.R.; Águas, A.C.P.; Rainer, A.; Forte, G. Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering. Sensors 2015, 15, 31142-31170.

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