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Article

A Multi-Channel, Flex-Rigid ECoG Microelectrode Array for Visual Cortical Interfacing

1
Institute for Microsensors, Actuators and Systems (IMSAS), Microsystems Center Bremen (MCB), University of Bremen, Bremen 28359, Germany
2
Institute for Brain Research, Center for Cognitive Sciences, University of Bremen, Bremen 28359, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Sensors 2015, 15(1), 832-854; https://doi.org/10.3390/s150100832
Received: 21 August 2014 / Accepted: 18 December 2014 / Published: 6 January 2015
(This article belongs to the Section Physical Sensors)
High-density electrocortical (ECoG) microelectrode arrays are promising signal-acquisition platforms for brain-computer interfaces envisioned, e.g., as high-performance communication solutions for paralyzed persons. We propose a multi-channel microelectrode array capable of recording ECoG field potentials with high spatial resolution. The proposed array is of a 150 mm2 total recording area; it has 124 circular electrodes (100, 300 and 500 µm in diameter) situated on the edges of concentric hexagons (min. 0.8 mm interdistance) and a skull-facing reference electrode (2.5 mm2 surface area). The array is processed as a free-standing device to enable monolithic integration of a rigid interposer, designed for soldering of fine-pitch SMD-connectors on a minimal assembly area. Electrochemical characterization revealed distinct impedance spectral bands for the 100, 300 and 500 µm-type electrodes, and for the array’s own reference. Epidural recordings from the primary visual cortex (V1) of an awake Rhesus macaque showed natural electrophysiological signals and clear responses to standard visual stimulation. The ECoG electrodes of larger surface area recorded signals with greater spectral power in the gamma band, while the skull-facing reference electrode provided higher average gamma power spectral density (γPSD) than the common average referencing technique. View Full-Text
Keywords: biomedical electrodes; implantable biomedical devices; in vivo; neural microtechnology; neural prosthesis biomedical electrodes; implantable biomedical devices; in vivo; neural microtechnology; neural prosthesis
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MDPI and ACS Style

Tolstosheeva, E.; Gordillo-González, V.; Biefeld, V.; Kempen, L.; Mandon, S.; Kreiter, A.K.; Lang, W. A Multi-Channel, Flex-Rigid ECoG Microelectrode Array for Visual Cortical Interfacing. Sensors 2015, 15, 832-854. https://doi.org/10.3390/s150100832

AMA Style

Tolstosheeva E, Gordillo-González V, Biefeld V, Kempen L, Mandon S, Kreiter AK, Lang W. A Multi-Channel, Flex-Rigid ECoG Microelectrode Array for Visual Cortical Interfacing. Sensors. 2015; 15(1):832-854. https://doi.org/10.3390/s150100832

Chicago/Turabian Style

Tolstosheeva, Elena, Víctor Gordillo-González, Volker Biefeld, Ludger Kempen, Sunita Mandon, Andreas K. Kreiter, and Walter Lang. 2015. "A Multi-Channel, Flex-Rigid ECoG Microelectrode Array for Visual Cortical Interfacing" Sensors 15, no. 1: 832-854. https://doi.org/10.3390/s150100832

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