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Open AccessArticle

A Method for Measuring the Volume of Transdermally Extracted Interstitial Fluid by a Three-Electrode Skin Resistance Sensor

State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin 300072, China
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Sensors 2014, 14(4), 7084-7095; https://doi.org/10.3390/s140407084
Received: 14 November 2013 / Revised: 31 March 2014 / Accepted: 9 April 2014 / Published: 22 April 2014
(This article belongs to the Special Issue On-Chip Sensors)
It is difficult to accurately measure the volume of transdermally extracted interstitial fluid (ISF), which is important for improving blood glucose prediction accuracy. Skin resistance, which is a good indicator of skin permeability, can be used to determine the volume of extracted ISF. However, it is a challenge to realize in vivo longitudinal skin resistance measurements of microareas. In this study, a three-electrode sensor was presented for measuring single-point skin resistance in vivo, and a method for determining the volume of transdermally extracted ISF using this sensor was proposed. Skin resistance was measured under static and dynamic conditions. The correlation between the skin resistance and the permeation rate of transdermally extracted ISF was proven. The volume of transdermally extracted ISF was determined using skin resistance. Factors affecting the volume prediction accuracy of transdermally extracted ISF were discussed. This method is expected to improve the accuracy of blood glucose prediction, and is of great significance for the clinical application of minimally invasive blood glucose measurement. View Full-Text
Keywords: blood glucose prediction; interstitial fluid; transdermal extraction; skin resistance sensor; volume measurement blood glucose prediction; interstitial fluid; transdermal extraction; skin resistance sensor; volume measurement
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MDPI and ACS Style

Li, D.; Wang, R.; Yu, H.; Li, G.; Sun, Y.; Liang, W.; Xu, K. A Method for Measuring the Volume of Transdermally Extracted Interstitial Fluid by a Three-Electrode Skin Resistance Sensor. Sensors 2014, 14, 7084-7095.

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