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Genetically Encoded Fluorescent Redox Probes

Department of Chemistry, University of California, 501 Big Springs Road, Riverside, CA 92521, USA
Author to whom correspondence should be addressed.
Sensors 2013, 13(11), 15422-15433;
Received: 19 October 2013 / Revised: 2 November 2013 / Accepted: 5 November 2013 / Published: 11 November 2013
(This article belongs to the Special Issue Fluorescent Biosensors)
PDF [593 KB, uploaded 21 June 2014]


Redox processes are involved in almost every cell of the body as a consequence of aerobic life. In the past decades, redox biology has been increasingly recognized as one of the key themes in cell signaling. The progress has been accelerated by development of fluorescent probes that can monitor redox conditions and dynamics in cells and cell compartments. This short paper focuses on fluorescent redox probes that are genetically encoded, and discusses their properties, molecular mechanism, advantages and pitfalls. Our recent work on reaction-based encoded probes that are responsive to particular redox signaling molecules is also reviewed. Future challenges and directions are also commented. View Full-Text
Keywords: redox signaling; fluorescent protein (FP)-based sensors; reaction-based probes; unnatural amino acids (UAAs); redox probes redox signaling; fluorescent protein (FP)-based sensors; reaction-based probes; unnatural amino acids (UAAs); redox probes

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ren, W.; Ai, H.-W. Genetically Encoded Fluorescent Redox Probes. Sensors 2013, 13, 15422-15433.

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