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Sensors 2012, 12(5), 5586-5595;

The Release of Immunosuppressive Factor(s) in Young Males Following Exercise

China Institute of Sport Science, 11 Tiyuguan Road, Dongcheng District, Beijing 100061, China
School of Physical Education and Sports, Macao Polytechnic Institute, Macao, China
Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Department of Physical Education, Hong Kong Baptist University, Hong Kong, China
Institute of Clinical Exercise and Health Sciences, School of Science, University of the West of Scotland, Hamilton, Scotland, UK
Author to whom correspondence should be addressed.
Received: 20 March 2012 / Revised: 18 April 2012 / Accepted: 27 April 2012 / Published: 2 May 2012
(This article belongs to the Special Issue Biomarkers and Nanosensors: New Approaches for Biology and Medicine)
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It has been shown that a suppressive protein, acting as an immune suppressor, is generated in animals and humans under particular stresses. However, studies related to immunosuppressive factors in response to the stress resulting from acute exercise are limited. This study compares the effects of pre- and post-exercise human serum on concanavalin A stimulated lymphocyte proliferation of mice. In the present study, blood samples in eight male undergraduates (age 21 ± 0.7 years) were taken before and immediately after ten sets of exercise consisting of 15 free and 30 10-kg loaded squat jumps in each set. The suppression of lymphocyte proliferation was analysed with high pressure liquid chromatography. It was noted from the result of gel chromatography columns that the post-exercise values of the suppression of lymphocyte proliferation, in comparison to corresponding pre-exercise values, were generally greater with significant differences observed in 7.5th–9th min post-exercise eluates (P < 0.05). Such findings suggest that intense eccentric type exercise may lead to generation of immunosuppressive factor(s) in young males. View Full-Text
Keywords: exercise; immunosuppressive factor; delayed onset muscle soreness exercise; immunosuppressive factor; delayed onset muscle soreness
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Tian, Y.; Nie, J.; Tong, T.K.; Baker, J.S. The Release of Immunosuppressive Factor(s) in Young Males Following Exercise. Sensors 2012, 12, 5586-5595.

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