Next Article in Journal
A Vocal-Based Analytical Method for Goose Behaviour Recognition
Next Article in Special Issue
A Variant Quorum Sensing System in Aeromonas veronii MTCC 3249
Previous Article in Journal
Robust Facial Expression Recognition via Compressive Sensing
Previous Article in Special Issue
N-Acyl Homoserine Lactones in Diverse Pectobacterium and Dickeya Plant Pathogens: Diversity, Abundance, and Involvement in Virulence
Open AccessArticle

A Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication

Department of Chemistry and Biochemistry, University of Maryland, Building 091, College Park, MD 20742, USA
*
Author to whom correspondence should be addressed.
Sensors 2012, 12(3), 3762-3772; https://doi.org/10.3390/s120303762
Received: 29 December 2011 / Revised: 26 February 2012 / Accepted: 15 March 2012 / Published: 21 March 2012
The universal quorum sensing autoinducer, AI-2, is utilized by several bacteria. Analogs of AI-2 have the potential to modulate bacterial behavior. Selectively quenching the communication of a few bacteria, in the presence of several others in an ecosystem, using analogs of AI-2 is non-trivial due to the ubiquity of AI-2 processing receptors in many bacteria that co-exist. Herein, we demonstrate that when an AI-2 analog, isobutyl DPD (which has been previously shown to be a quorum sensing, QS, quencher in both Escherichia coli and Salmonella typhimurium) is modified with ester groups, which get hydrolyzed once inside the bacterial cells, only QS in E. coli, but not in S. typhimurium, is inhibited. The origin of this differential QS inhibition could be due to differences in analog permeation of the bacterial membranes or ester hydrolysis rates. Such differences could be utilized to selectively target QS in specific bacteria amongst a consortium of other species that also use AI-2 signaling. View Full-Text
Keywords: AI-2; DPD analog; quorum sensing inhibitor; ester pro-drug; lsr expression; autoinducer cell permeation; autoinducer processing; enteric bacteria AI-2; DPD analog; quorum sensing inhibitor; ester pro-drug; lsr expression; autoinducer cell permeation; autoinducer processing; enteric bacteria
Show Figures

Graphical abstract

MDPI and ACS Style

Guo, M.; Gamby, S.; Nakayama, S.; Smith, J.; Sintim, H.O. A Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication. Sensors 2012, 12, 3762-3772.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop