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Sensors 2012, 12(3), 3131-3144;

A Novel In Vitro Sensing Configuration for Retinal Physiology Analysis of a Sub-Retinal Prosthesis

Inter-university Semiconductor Research Center, Automation System Research Institute, School of Electrical Engineering and Computer Science, Seoul National University, Seoul 151-744, Korea
Department of Physiology, Chungbuk National University, Cheongju 361-763, Korea
Department of Biomedical Engineering, Yonsei University, Wonju 220-710, Korea
Authors to whom correspondence should be addressed.
Received: 15 January 2012 / Revised: 27 February 2012 / Accepted: 27 February 2012 / Published: 6 March 2012
(This article belongs to the Section Biosensors)
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This paper presents a novel sensing configuration for retinal physiology analysis, using two microelectrode arrays (MEAs). In order to investigate an optimized stimulation protocol for a sub-retinal prosthesis, retinal photoreceptor cells are stimulated, and the response of retinal ganglion cells is recorded in an in vitro environment. For photoreceptor cell stimulation, a polyimide-substrate MEA is developed, using the microelectromechanical systems (MEMS) technology. For ganglion cell response recording, a conventional glass-substrate MEA is utilized. This new sensing configuration is used to record the response of retinal ganglion cells with respect to three different stimulation methods (monopolar, bipolar, and dual-monopolar stimulation methods). Results show that the geometrical relation between the stimulation microelectrode locations and the response locations seems very low. The threshold charges of the bipolar stimulation and the monopolar stimulation are in the range of 10~20 nC. The threshold charge of the dual-monopolar stimulation is not obvious. These results provide useful guidelines for developing a sub-retinal prosthesis. View Full-Text
Keywords: sensing configuration; microelectrode array; sub-retinal prosthesis sensing configuration; microelectrode array; sub-retinal prosthesis

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Koo, K.-I.; Lee, S.; Yee, J.H.; Ryu, S.B.; Kim, K.H.; Goo, Y.S.; Cho, D.-I. A Novel In Vitro Sensing Configuration for Retinal Physiology Analysis of a Sub-Retinal Prosthesis. Sensors 2012, 12, 3131-3144.

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