1H,1H,7H-Dodecafluoroheptyl Pentafluorobenzoate

Round 1

Reviewer 1 Report

The authors, D. A. Parkhomenko et al., reported a synthesis of 1H,1H,7H-dodecafluoroheptyl pentafluorobenzoate (1). They provided NMRs, MS, IR, UV-Vis, and HPLC chromatogram on the SI, which support the reliability of the structure of 1.

It is a bit disappointing that they did not attempt to improve the yield of 1 in approach III, and each of the efficient synthetic methods (approaches I and II) relies on classical techniques. Nevertheless, I think the paper would be suitable for publication on Molbank.

Issues:

1. Compound number should be shown in bold, not italic.
2. Line 45; Please insert a half-space between the reaction time and the unit.
3. Experimental section; Were the carboxylic acid and the alcohol added in a 1:1 ratio, rather than 1:2 in approach I? The experimental procedure differs from the description in the main text. Please check the paper carefully again.

Author Response

We would like to thank the reviewer for reviewing our article and pointing out its shortcomings. Below are the responses to the reviewer's comments.

Issues 1 and 2: Compound number should be shown in bold, not italic; Line 45; Please insert a half-space between the reaction time and the unit.

Response: We have updated the text according reviewer's comment

Issues 3: Experimental section; Were the carboxylic acid and the alcohol added in a 1:1 ratio, rather than 1:2 in approach I? The experimental procedure differs from the description in the main text. Please check the paper carefully again.

Response: We thank the reviewer for pointing this out and apologize for our oversight. Experiments were done with both 1:1 and 1:2 ratios, and we have added a description of the synthesis with the 1:2 ratio. We have also amended the discussion of these experiments, all changes are highlighted in yellow.