Stereoselective Preparation of (4S)-1-Methyl-4-propyl-L-proline Commencing from (cis)-4-Hydroxy-L-proline

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This manuscript describes an efficient synthesis of (4S)-1-methyl-4-propyl-L-proline, an epimer of the amino-acid moiety of lincomycin, from 4-hydroxy-L-priline in 7 steps.

The current work would be a practical method for the preparation of the target molecule and would support the SAR research for the anti-biotics such as lincomycin.

Chemistries described in this paper would be a nice piece of work and of interest for a number of researchers in this field.

I recommend this manuscript for publication in Molbank without any revision.

 

Author Response

Comments: This manuscript describes an efficient synthesis of (4S)-1-methyl-4-propyl-L-proline, an epimer of the amino-acid moiety of lincomycin, from 4-hydroxy-L-priline in 7 steps.

The current work would be a practical method for the preparation of the target molecule and would support the SAR research for the anti-biotics such as lincomycin.

Chemistries described in this paper would be a nice piece of work and of interest for a number of researchers in this field.

I recommend this manuscript for publication in Molbank without any revision.

 

Response: We thank Reviewer 1 for their support of our work!

Reviewer 2 Report

Comments and Suggestions for Authors

This is a wonderful synthesis, and I think this manuscript is acceptable. Some suggestions for providing better service to readers:

1. The description of crystal analysis in the manuscriptis inconsistent with the version cited.
2. 2. In mass spectrometry, for the relatively distinct peaks, it is necessary to determine with which substances the target compound combines to generate those peaks?

Author Response

his is a wonderful synthesis, and I think this manuscript is acceptable. Some suggestions for providing better service to readers:

1. The description of crystal analysis in the manuscriptis inconsistent with the version cited.
2. 2. In mass spectrometry, for the relatively distinct peaks, it is necessary to determine with which substances the target compound combines to generate those peaks?

Response: We thank Reviewer 2 for their support! We have checked the crystal analysis carefully and have found no inconsistencies. It can be quite challenging to determine the nature of the other peaks in the mass spectrometry without collision-induced dissociation, which our instrument lacks. We have thus only looked for the molecular ion.