(E)-N-(3-(5-(3-Acetamidopropyl)-3,6-dioxopiperazin-2-yl)propyl)-5-hydroxy-3-methylpent-2-enamide

Round 1

Reviewer 1 Report

Manuscript presented by Gagan Preet et al. shows a short note study about a synthesis of (E)-N-(3-(5-(3-acetamidopropyl)-3,6-dioxopiperazin-2-yl)pro- 2 pyl)-5-hydroxy-3-methylpent-2-enamide. The topic is very important due to potential biological application of this class of organic compounds. Thanks to the Authors for conducting this intriguing study.

An already well written and prepared manuscript. Easy to read and follow. Some aspects should be improved. I recommend the article to publish in Molbank but first the paper should be corrected. My decision – reconsider after minor revision. Comments to be considered, in order to further improve the manuscript quality:

(1)  Please clearly define which compound is new connection? If the compound is not new connection, provide appropriate references in order to comparison of compound characteristics such as melting point. Please put this information in the introduction section.

(2)  Better will change “Results” section on “Results and discussion”.

(3)  How was the purity of the obtained compound confirmed?

(4)  Please add information about melting point and IR analysis with discussion.

(5)  Please add full information (with details) about the NMR technique e.g. inert standard ect.

(6)  Please check if all Figures and Table are cited in main text.

(7)  The Authors have to add a conclusion part.

(8)  Superscripts and subscripts as well as commas and dots should be checked and correct. Avoid extra or lack of spaces and enters. Remove unnecessary capital letters in the text. Correct in whole manuscript.

Author Response

please see the attachment

Author Response File: Author Response.pdf