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N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia
Author to whom correspondence should be addressed.
Academic Editor: Raffaella Mancuso
Molbank 2022, 2022(3), M1411;
Received: 5 July 2022 / Revised: 14 July 2022 / Accepted: 19 July 2022 / Published: 20 July 2022
(This article belongs to the Section Organic Synthesis)
Conjugates of 3H-1,2-dithiol-3-ones with various biologically active compounds are intensively investigated. Although many derivatives of this class have been described in the literature, the compounds containing two dithiole cycles have been explored much less. In this communication, it was shown that the reaction of 4,5-dichloro-3H-1,2-dithiol-3-one with piperazine can selectively lead to the mono-product, 4-chloro-5-piperazin-1-yl-3H-1,2-dithiol-3-one and bis-product, 5,5′-(piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one). The structure of the synthesized compounds was established by elemental analysis, high resolution mass-spectrometry, 1H, 13C NMR and IR spectroscopy, and mass-spectrometry. View Full-Text
Keywords: 3H-1,2-Dithiole-3-ones; piperazine; nucleophilic substitution; 5,5′-(piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one) 3H-1,2-Dithiole-3-ones; piperazine; nucleophilic substitution; 5,5′-(piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)
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MDPI and ACS Style

Ogurtsov, V.A.; Rakitin, O.A. 5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one). Molbank 2022, 2022, M1411.

AMA Style

Ogurtsov VA, Rakitin OA. 5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one). Molbank. 2022; 2022(3):M1411.

Chicago/Turabian Style

Ogurtsov, Vladimir A., and Oleg A. Rakitin. 2022. "5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)" Molbank 2022, no. 3: M1411.

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