5,5&prime;-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)

Ogurtsov, Vladimir A.; Rakitin, Oleg A.

doi:10.3390/M1411

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5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)

Vladimir A. Ogurtsov

^* and

Oleg A. Rakitin

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia

Author to whom correspondence should be addressed.

Academic Editor: Raffaella Mancuso

Molbank 2022, 2022(3), M1411; https://doi.org/10.3390/M1411

Received: 5 July 2022 / Revised: 14 July 2022 / Accepted: 19 July 2022 / Published: 20 July 2022

(This article belongs to the Section Organic Synthesis)

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Abstract

Conjugates of 3H-1,2-dithiol-3-ones with various biologically active compounds are intensively investigated. Although many derivatives of this class have been described in the literature, the compounds containing two dithiole cycles have been explored much less. In this communication, it was shown that the reaction of 4,5-dichloro-3H-1,2-dithiol-3-one with piperazine can selectively lead to the mono-product, 4-chloro-5-piperazin-1-yl-3H-1,2-dithiol-3-one and bis-product, 5,5′-(piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one). The structure of the synthesized compounds was established by elemental analysis, high resolution mass-spectrometry, ¹H, ¹³C NMR and IR spectroscopy, and mass-spectrometry. View Full-Text

Keywords: 3H-1,2-Dithiole-3-ones; piperazine; nucleophilic substitution; 5,5′-(piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)

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Ogurtsov, V.A.; Rakitin, O.A. 5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one). Molbank 2022, 2022, M1411. https://doi.org/10.3390/M1411

AMA Style

Ogurtsov VA, Rakitin OA. 5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one). Molbank. 2022; 2022(3):M1411. https://doi.org/10.3390/M1411

Chicago/Turabian Style

Ogurtsov, Vladimir A., and Oleg A. Rakitin. 2022. "5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)" Molbank 2022, no. 3: M1411. https://doi.org/10.3390/M1411

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5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)

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