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Short Note

2-(2-(4-Methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic Acid

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Leninsky Pr., 47, 119991 Moscow, Russia
Author to whom correspondence should be addressed.
Academic Editor: Stefano D’Errico
Molbank 2022, 2022(1), M1315;
Received: 21 December 2021 / Revised: 7 January 2022 / Accepted: 11 January 2022 / Published: 13 January 2022
(This article belongs to the Section Organic Synthesis)
A simple and efficient protocol for the synthesis of the previously unknown 2-(2-(4-methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic acid was elaborated. The suggested method is based on the telescoped multicomponent reaction of 8-hydroxyquinoline, 4-methylglyoxal, and Meldrum’s acid. The studied process includes the initial interaction of the starting compounds in MeCN followed by intramolecular cyclization to the target product in refluxing acetic acid. The advantage of this approach is the application of readily available starting materials, atom economy, and a simple work-up procedure. The structure of the synthesized furylacetic acid derivative was proven by 1H, 13C, 2D-NMR, IR spectroscopy, and high-resolution mass spectrometry. View Full-Text
Keywords: 8-hydroxyquinoline; arylglyoxals; Meldrum’s acid; telescoped process 8-hydroxyquinoline; arylglyoxals; Meldrum’s acid; telescoped process
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MDPI and ACS Style

Lichitsky, B.V.; Komogortsev, A.N.; Melekhina, V.G. 2-(2-(4-Methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic Acid. Molbank 2022, 2022, M1315.

AMA Style

Lichitsky BV, Komogortsev AN, Melekhina VG. 2-(2-(4-Methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic Acid. Molbank. 2022; 2022(1):M1315.

Chicago/Turabian Style

Lichitsky, Boris V., Andrey N. Komogortsev, and Valeriya G. Melekhina. 2022. "2-(2-(4-Methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic Acid" Molbank 2022, no. 1: M1315.

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