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Short Note

(E)-1-(3-Benzoyl-4-phenyl-1H-pyrrol-1-yl)-3-phenylprop-2-en-1-one

Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
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Academic Editor: Stefano D’Errico
Molbank 2022, 2022(1), M1314; https://doi.org/10.3390/M1314
Received: 17 December 2021 / Revised: 4 January 2022 / Accepted: 11 January 2022 / Published: 13 January 2022
Over the last decade, there has been an increasing effort to fight inflammatory conditions establishing new multitarget approaches. Chronic inflammation is implicated in many multifactorial diseases, constituting a great economic burden and a chronic health problem. In an attempt to develop new potent multifunctional anti-inflammatory agents, a cinnamic-pyrrole hybrid (6) was synthesized and screened for its antioxidant and anti-Lipoxygenase potential. The new compound, in comparison with its pyrrole precursor (4), showed improved biological activities. In silico calculations were performed to predict its drug-likeness. The examined derivative is considered orally bioavailable according to Lipinski’s rule of five. Compound 6 could be used as a lead for the synthesis of more effective hybrids. View Full-Text
Keywords: inflammation; hybrids; cinnamic acid; pyrroles; antioxidant activity; LOX inflammation; hybrids; cinnamic acid; pyrroles; antioxidant activity; LOX
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MDPI and ACS Style

Noti, V.; Hadjipavlou-Litina, D. (E)-1-(3-Benzoyl-4-phenyl-1H-pyrrol-1-yl)-3-phenylprop-2-en-1-one. Molbank 2022, 2022, M1314. https://doi.org/10.3390/M1314

AMA Style

Noti V, Hadjipavlou-Litina D. (E)-1-(3-Benzoyl-4-phenyl-1H-pyrrol-1-yl)-3-phenylprop-2-en-1-one. Molbank. 2022; 2022(1):M1314. https://doi.org/10.3390/M1314

Chicago/Turabian Style

Noti, Viola, and Dimitra Hadjipavlou-Litina. 2022. "(E)-1-(3-Benzoyl-4-phenyl-1H-pyrrol-1-yl)-3-phenylprop-2-en-1-one" Molbank 2022, no. 1: M1314. https://doi.org/10.3390/M1314

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