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Dimethyl 2-(2,4-Diamino-3-cyano-5H-chromeno[2,3-b]pyridin-5-yl)malonate
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6′-Amino-5,7-dibromo-2-oxo-3′-(trifluoromethyl)-1′H-spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-5′-carbonitrile

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia
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Academic Editor: Hideto Miyabe
Molbank 2022, 2022(1), M1309; https://doi.org/10.3390/M1309
Received: 8 December 2021 / Revised: 20 December 2021 / Accepted: 22 December 2021 / Published: 23 December 2021
(This article belongs to the Section Organic Synthesis)
The multicomponent reactions are environmentally benign synthetic methods of building-up of complex molecules and several levels of structural diversity for diverse applications. Spirooxindoles are an important synthetic target possessing extended biological activity and drug discovery applications. In this communication, the multicomponent transformation of 5,7-dibromoisatin, malononitrile, and 5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one in EtOH at reflux in the presence of sodium acetate was carefully investigated to give 6′-amino-5,7-dibromo-2-oxo-3′-(trifluoromethyl)-1′H-spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-5′-carbonitrile in excellent yield. The structure of the new compound was established by means of elemental analysis, mass and nuclear magnetic resonance, and infrared spectroscopy. View Full-Text
Keywords: 5,7-dibromoisatin; malononitrile; 5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one; spiro[indole-3,4′-pyrano[2,3-c]pyrazole]; multicomponent reactions 5,7-dibromoisatin; malononitrile; 5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one; spiro[indole-3,4′-pyrano[2,3-c]pyrazole]; multicomponent reactions
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MDPI and ACS Style

Ryzhkova, Y.E.; Kalashnikova, V.M.; Elinson, M.N. 6′-Amino-5,7-dibromo-2-oxo-3′-(trifluoromethyl)-1′H-spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-5′-carbonitrile. Molbank 2022, 2022, M1309. https://doi.org/10.3390/M1309

AMA Style

Ryzhkova YE, Kalashnikova VM, Elinson MN. 6′-Amino-5,7-dibromo-2-oxo-3′-(trifluoromethyl)-1′H-spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-5′-carbonitrile. Molbank. 2022; 2022(1):M1309. https://doi.org/10.3390/M1309

Chicago/Turabian Style

Ryzhkova, Yuliya E., Varvara M. Kalashnikova, and Michail N. Elinson. 2022. "6′-Amino-5,7-dibromo-2-oxo-3′-(trifluoromethyl)-1′H-spiro[indoline-3,4′-pyrano[2,3-c]pyrazole]-5′-carbonitrile" Molbank 2022, no. 1: M1309. https://doi.org/10.3390/M1309

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