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Communication

New Derivatives of Lupeol and Their Biological Activity

1
Department of Organic Chemistry, Faculty of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 72711, Vietnam
2
Faculty of Environmental Science, Sai Gon University, Ho Chi Minh City 72711, Vietnam
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Faculty of Basic Sciences, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, Dist. 5, Ho Chi Minh City 700000, Vietnam
4
CirTech Institute, HUTECT University, Ho Chi Minh City 72324, Vietnam
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Research Unit in Natural Products Chemistry and Bioactivities, Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang 52190, Thailand
*
Authors to whom correspondence should be addressed.
Academic Editors: Giovanni Ribaudo and Rodrigo Abonia
Molbank 2021, 2021(4), M1306; https://doi.org/10.3390/M1306
Received: 16 November 2021 / Revised: 26 November 2021 / Accepted: 6 December 2021 / Published: 10 December 2021
(This article belongs to the Special Issue Synthesis of Flavonoids or Other Nature-Inspired Small Molecules)
The natural product lupeol (1) was isolated from Bombax ceiba leaves, which were used as starting material in the semisynthetic approach. Three new derivatives (2a, 2b, and 3) were synthesized using oxidation and aldolization. Their chemical structures were elucidated by spectroscopic analyses (HRESIMS and NMR). Compounds 3 showed significant α-glucosidase inhibition with an IC50 value of 202 µM, whereas 2a and 2b were inactive. View Full-Text
Keywords: lupeol derivative; benzylidene derivative; α-glucosidase inhibition; Oxone® lupeol derivative; benzylidene derivative; α-glucosidase inhibition; Oxone®
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MDPI and ACS Style

Le, H.-T.-T.; Chau, Q.-C.; Duong, T.-H.; Tran, Q.-T.-P.; Pham, N.-K.-T.; Nguyen, T.-H.-T.; Nguyen, N.-H.; Sichaem, J. New Derivatives of Lupeol and Their Biological Activity. Molbank 2021, 2021, M1306. https://doi.org/10.3390/M1306

AMA Style

Le H-T-T, Chau Q-C, Duong T-H, Tran Q-T-P, Pham N-K-T, Nguyen T-H-T, Nguyen N-H, Sichaem J. New Derivatives of Lupeol and Their Biological Activity. Molbank. 2021; 2021(4):M1306. https://doi.org/10.3390/M1306

Chicago/Turabian Style

Le, Hoang-Thuy-Tien, Quoc-Cuong Chau, Thuc-Huy Duong, Quyen-Thien-Phuc Tran, Nguyen-Kim-Tuyen Pham, Thi-Hoai-Thu Nguyen, Ngoc-Hong Nguyen, and Jirapast Sichaem. 2021. "New Derivatives of Lupeol and Their Biological Activity" Molbank 2021, no. 4: M1306. https://doi.org/10.3390/M1306

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