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Regioselective Synthesis of 5-Propyl-2-((trityloxy)methyl)thiophene-3-carbaldehyde

by 1,2
1
Department of Chemistry, Indian Institute Technology Kharagpur, Kharagpur 721302, India
2
Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
Academic Editor: Nicholas E. Leadbeater
Molbank 2021, 2021(4), M1289; https://doi.org/10.3390/M1289
Received: 31 August 2021 / Revised: 8 October 2021 / Accepted: 10 October 2021 / Published: 14 October 2021
(This article belongs to the Section Organic Synthesis)
5-propyl-2-((trityloxy)methyl)thiophene-3-carbaldehyde was synthesized by using the concept of chemo- and regioselective Br/Li exchange reaction from 3-bromo-5-propyl-2-((trityloxy)methyl)thiophene. This is a five-step protocol starting from thiophene with an overall yield of 33%. These lithium/halogen exchange reactions were carried out at −78 °C to rt over the period of 1 to 18 h depending on the reactivity of electrophiles. View Full-Text
Keywords: thiophene; regioselective synthesis; bromine; n-BuLi; lithium thiophene; regioselective synthesis; bromine; n-BuLi; lithium
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MDPI and ACS Style

Bar, S. Regioselective Synthesis of 5-Propyl-2-((trityloxy)methyl)thiophene-3-carbaldehyde. Molbank 2021, 2021, M1289. https://doi.org/10.3390/M1289

AMA Style

Bar S. Regioselective Synthesis of 5-Propyl-2-((trityloxy)methyl)thiophene-3-carbaldehyde. Molbank. 2021; 2021(4):M1289. https://doi.org/10.3390/M1289

Chicago/Turabian Style

Bar, Sukanta. 2021. "Regioselective Synthesis of 5-Propyl-2-((trityloxy)methyl)thiophene-3-carbaldehyde" Molbank 2021, no. 4: M1289. https://doi.org/10.3390/M1289

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