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Communication

Practical and Asymmetric Synthesis of Apremilast Using Ellman’s Sulfinamide as a Chiral Auxiliary

by 1 and 1,2,*
1
School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Luoyu Road 1037, Wuhan 430074, China
2
Shenzhen Huazhong University of Science & Technology Research Institute, Yuexing No. 3 street 9, Shenzhen 518063, China
*
Author to whom correspondence should be addressed.
Academic Editor: Raffaella Mancuso
Molbank 2021, 2021(3), M1275; https://doi.org/10.3390/M1275
Received: 31 July 2021 / Revised: 14 August 2021 / Accepted: 24 August 2021 / Published: 2 September 2021
(This article belongs to the Section Organic Synthesis)
Herein, we described a new protocol for the asymmetric synthesis of apremilast using tert-butanesulfinamide as a chiral auxiliary. This synthetic route consisted of four steps starting from the commercially available 3-hydroxy-4-methoxybenzaldehyde, and apremilast was accordingly obtained in an overall 56% yield and with 95.5% ee. View Full-Text
Keywords: apremilast; asymmetric synthesis; Ellman’s sulfinamide; chiral auxiliary apremilast; asymmetric synthesis; Ellman’s sulfinamide; chiral auxiliary
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MDPI and ACS Style

Wang, B.; Zhong, F. Practical and Asymmetric Synthesis of Apremilast Using Ellman’s Sulfinamide as a Chiral Auxiliary. Molbank 2021, 2021, M1275. https://doi.org/10.3390/M1275

AMA Style

Wang B, Zhong F. Practical and Asymmetric Synthesis of Apremilast Using Ellman’s Sulfinamide as a Chiral Auxiliary. Molbank. 2021; 2021(3):M1275. https://doi.org/10.3390/M1275

Chicago/Turabian Style

Wang, Bofei, and Fangrui Zhong. 2021. "Practical and Asymmetric Synthesis of Apremilast Using Ellman’s Sulfinamide as a Chiral Auxiliary" Molbank 2021, no. 3: M1275. https://doi.org/10.3390/M1275

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