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Short Note

N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]quinoline]-acetamide

1
School of Pharmacy, Macau University of Science and Technology, Macau 999078, China
2
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
3
Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Bartolo Gabriele
Molbank 2021, 2021(2), M1213; https://doi.org/10.3390/M1213
Received: 20 April 2021 / Revised: 7 May 2021 / Accepted: 13 May 2021 / Published: 20 May 2021
(This article belongs to the Special Issue Synthesis of Flavonoids or Other Nature-Inspired Small Molecules)
The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of 4-azido-7-chloroquinoline with an alkyne derivative of acetaminophen. The compound was fully characterized by Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV) and high-resolution mass spectroscopies (HRMS). This compound was screened in vitro with different normal and cancer cell lines. The drug likeness of the compound was also investigated by predicting its pharmacokinetic properties. View Full-Text
Keywords: 1,2,3-triazole; anticancer; aminoquinoline; hybrid compound 1,2,3-triazole; anticancer; aminoquinoline; hybrid compound
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MDPI and ACS Style

Coghi, P.; Ng, J.P.L.; Nasim, A.A.; Wong, V.K.W. N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]quinoline]-acetamide. Molbank 2021, 2021, M1213. https://doi.org/10.3390/M1213

AMA Style

Coghi P, Ng JPL, Nasim AA, Wong VKW. N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]quinoline]-acetamide. Molbank. 2021; 2021(2):M1213. https://doi.org/10.3390/M1213

Chicago/Turabian Style

Coghi, Paolo; Ng, Jerome P.L.; Nasim, Ali A.; Wong, Vincent K.W. 2021. "N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]quinoline]-acetamide" Molbank 2021, no. 2: M1213. https://doi.org/10.3390/M1213

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