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Department of Organic and Pharmaceutical Technologies, Odessa National Polytechnic University, 65044 Odessa, Ukraine
Department of Analytical and Toxicological Chemistry, Odessa I.I. Mechnikov National University, 65082 Odessa, Ukraine
A.V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine, 65080 Odessa, Ukraine
Author to whom correspondence should be addressed.
Molbank 2020, 2020(4), M1164;
Received: 28 September 2020 / Revised: 17 October 2020 / Accepted: 19 October 2020 / Published: 26 October 2020
(This article belongs to the Special Issue Synthesis of Flavonoids or Other Nature-Inspired Small Molecules)
2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide was obtained in 80% yield via the Einhorn variation of the Schotten–Baumann method by (+)-camphor hydrazide condensation with valproic acid (VPA) chloride. The structure of the titled compound was verified by Raman, FTIR, 1H-NMR, and 13C-NMR spectral analysis along with FAB-mass spectrometry. Thermal properties of synthesized derivative were elucidated by DSC and its purity by HPLC. The compound was successfully tested as a potential anticonvulsant agent based on models of chemically- and electrically-induced seizures. View Full-Text
Keywords: hydrazone; (+)-camphor; valproic acid; technology; terpenoid; anticonvulsant activity hydrazone; (+)-camphor; valproic acid; technology; terpenoid; anticonvulsant activity
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Nesterkina, M.; Barbalat, D.; Rakipov, I.; Kravchenko, I. 2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide. Molbank 2020, 2020, M1164.

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