Next Article in Journal
(E)-4-(3-(3-(4-Methoxyphenyl)acryloyl)phenoxy)butyl 2-Hydroxybenzoate
Next Article in Special Issue
3-(tert-Butyl)-N-(4-methoxybenzyl)-1-methyl-1H-pyrazol-5-amine
Previous Article in Journal
(Z)-5-(3′,4′-Bis(benzyloxy)benzylidene)furan-2(5H)-one
Previous Article in Special Issue
Ethyl 1-Butyl-2-(2-hydroxy-4-methoxyphenyl)-1H-benzo[d]imidazole-5-carboxylate
Open AccessCommunication

Synthesis of 1,5-Disubstituted Tetrazoles in Aqueous Micelles at Room Temperature

1
Laboratory of Organic Synthesis, Physico-Chemistry, Biomolecules and Environment (LSPBE), Department of Chemical Engineering, Faculty of Chemistry, University of Sciences and Technology of Oran “Mohamed Boudiaf”—USTOMB, El Mnaouar BP 1505, Bir El Djir 31000, Oran, Algeria
2
Laboratory of Chemistry, Department of Chemical Engineering, Faculty of Chemistry, University of Sciences and Technology of Oran “Mohamed Boudiaf”—USTOMB, El Mnaouar BP 1505, Bir El Djir 31000, Oran, Algeria
3
Laboratory of Chemistry and Electrochemistry of Metal Complex, Department of Chemical Engineering, Faculty of Chemistry, University of Sciences and Technology of Oran “Mohamed Boudiaf”—USTOMB, El Mnaouar BP 1505, Bir El Djir 31000, Oran, Algeria
*
Authors to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2021, 2021(1), M1194; https://doi.org/10.3390/M1194
Received: 17 January 2021 / Revised: 4 March 2021 / Accepted: 4 March 2021 / Published: 9 March 2021
(This article belongs to the Special Issue Heterocycle Reactions)
The ongoing study is a Ugi-azide four-component reaction for the synthesis of 1,5-disubstituted tetrazole(1,5-DST), which involves an aldehyde, different amines, isocyanides, and as azide’s source the Trimethylsilylazide (TMSN3), in water as solvent using as catalyst the tetradecyltrimethylammonium bromide (TTAB) with a load of (10% mole), which provides a hydrophobic micellar reaction site. This approach is a step toward a green chemistry reaction of 1,5 disubstituted tetrazole. A serie of 1, 5- disubstituted tetrazole was synthesized by engaging a large substrate scope, leading to yields between 43% and 56%, which are compared afterwards with those obtained with methanol as solvent. The results were confirmed by HRMS, IR, and 1D NMR experiments. View Full-Text
Keywords: tetrazole; Ugi-azide multicomponent reaction instead of Ugiazide reaction; Ugi-azide multicomponent reaction; micellar catalysis; green chemistry tetrazole; Ugi-azide multicomponent reaction instead of Ugiazide reaction; Ugi-azide multicomponent reaction; micellar catalysis; green chemistry
Show Figures

Figure 1

MDPI and ACS Style

Abdessalam, M.; Sidhoum, M.A.; Zradni, F.-Z.; Ilikti, H. Synthesis of 1,5-Disubstituted Tetrazoles in Aqueous Micelles at Room Temperature. Molbank 2021, 2021, M1194. https://doi.org/10.3390/M1194

AMA Style

Abdessalam M, Sidhoum MA, Zradni F-Z, Ilikti H. Synthesis of 1,5-Disubstituted Tetrazoles in Aqueous Micelles at Room Temperature. Molbank. 2021; 2021(1):M1194. https://doi.org/10.3390/M1194

Chicago/Turabian Style

Abdessalam, Mohammed; Sidhoum, Madjid A.; Zradni, Fatima-Zohra; Ilikti, Hocine. 2021. "Synthesis of 1,5-Disubstituted Tetrazoles in Aqueous Micelles at Room Temperature" Molbank 2021, no. 1: M1194. https://doi.org/10.3390/M1194

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop