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3,5-Bis((E)-4-methoxybenzylidene)-1-(2-morpholinoethyl)piperidin-4-one

1
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Kampus Bina Widya, Jalan H.R. Subrantas KM. 12.5, Pekanbaru 28293, Indonesia
2
Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Jalan Kamboja, Pekanbaru 28293, Indonesia
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(4), M1159; https://doi.org/10.3390/M1159
Received: 25 August 2020 / Revised: 4 October 2020 / Accepted: 5 October 2020 / Published: 8 October 2020
(This article belongs to the Section Organic Synthesis)
The 3,5-bis((E)-4-methoxybenzylidene)-1-(2-morpholinoethyl)piperidin-4-one (3) compound was synthesized by a two-step reaction with 92% yield. The chemical structure of compound 3 was confirmed by IR, NMR, and mass spectrometry. The title compound was screened for its anti-dengue activity against DENV2 NS2B-NS3 protease and showed 39.09% inhibitory activity at 200 µg/mL. View Full-Text
Keywords: anti-dengue; conjugated curcumin; DEN2 NS2B/NS3 protease; mono-ketone curcumin anti-dengue; conjugated curcumin; DEN2 NS2B/NS3 protease; mono-ketone curcumin
MDPI and ACS Style

Kuswardani, T.; Herfindo, N.; Frimayanti, N.; Hendra, R.; Zamri, A. 3,5-Bis((E)-4-methoxybenzylidene)-1-(2-morpholinoethyl)piperidin-4-one. Molbank 2020, 2020, M1159.

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