Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy
Author to whom correspondence should be addressed.
Academic Editor: Fang-Rong Chang
Molbank 2020, 2020(3), M1144; https://doi.org/10.3390/M1144
Received: 10 June 2020 / Revised: 22 June 2020 / Accepted: 28 June 2020 / Published: 29 June 2020
(This article belongs to the Special Issue Synthesis of Flavonoids or Other Nature-Inspired Small Molecules)
On the basis of the knowledge from traditional herbal and folk medicine, flavonoids are among the most studied chemical classes of natural compounds for their potential activity as phosphodiesterase 5 (PDE5) inhibitors. We here describe the preparation of a semi-synthetic hydrazone derivative of quercetin, 2-(3,4-dihydroxyphenyl)-4-(2-(4-nitrophenyl)hydrazono)-4H-chromene-3,5,7-triol, that was obtained via a single-step modification of the natural compound. The product was characterized by NMR, mass spectrometry and HPLC. Preliminary molecular modeling studies suggest that this compound could efficiently interact with PDE5.