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Open AccessCommunication

Synthesis of (R) and (S)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4H-1,2,6-thiadiazin-4-ones

1
Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenis Str., Engomi, P. O. Box 22006, 1516 Nicosia, Cyprus
2
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
3
Department of Chemistry, University of Cyprus, P. O. Box 20537, 1678 Nicosia, Cyprus
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(2), M1139; https://doi.org/10.3390/M1139
Received: 4 May 2020 / Revised: 20 May 2020 / Accepted: 25 May 2020 / Published: 1 June 2020
(This article belongs to the Special Issue Heterocycle Reactions)
The reaction of 3,5-dichloro-4H-1,2,6-thiadiazin-4-one with (R) and (S)-1,3-dimethylpiperazines (1 equiv), in THF, at ca. 20 °C gives (R) and (S)-3-chloro-5-(2,4-dimethylpiperazin-1-yl)-4H-1,2,6-thiadiazin-4-ones in 70% and 68% yields, respectively. The new compounds were fully characterized. View Full-Text
Keywords: substitution; heterocycle; thiadiazine; piperazine; chirality substitution; heterocycle; thiadiazine; piperazine; chirality
MDPI and ACS Style

Kalogirou, A.S.; Asquith, C.R.M.; Koutentis, P.A. Synthesis of (R) and (S)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4H-1,2,6-thiadiazin-4-ones. Molbank 2020, 2020, M1139.

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