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6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine

1
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
2
Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
3
UK National Crystallography Service, School of Chemistry, University of Southampton, Highfield Campus, Southampton SO17 1BJ, UK
*
Author to whom correspondence should be addressed.
Molbank 2019, 2019(4), M1087; https://doi.org/10.3390/M1087 (registering DOI)
Received: 7 October 2019 / Accepted: 24 October 2019 / Published: 27 October 2019
We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2H-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation. We also performed routine characterization with 1H/13C-NMR and liquid chromatography (LC) and high-resolution mass spectra (HRMS). View Full-Text
Keywords: 2-methyl-2H-1,2,3-triazole; 4-anilino-quin(az)olines; conformational flexibility; hinge binder; kinase inhibitor design 2-methyl-2H-1,2,3-triazole; 4-anilino-quin(az)olines; conformational flexibility; hinge binder; kinase inhibitor design
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MDPI and ACS Style

Asquith, C.R.M.; Tizzard, G.J. 6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine. Molbank 2019, 2019, M1087.

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