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3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

1
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Jalan H.R. Subrantas KM. 12.5, Pekanbaru 28293, Indonesia
2
Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Jalan Kamboja, Pekanbaru 28293, Indonesia
*
Author to whom correspondence should be addressed.
Molbank 2019, 2019(4), M1088; https://doi.org/10.3390/M1088
Received: 9 October 2019 / Revised: 5 November 2019 / Accepted: 8 November 2019 / Published: 12 November 2019
(This article belongs to the Section Organic Synthesis)
A new analogue of fluorinated pyrazoline (compound 1) has been synthesized via one-pot three-component reaction under microwave irradiation. The structure of compound 1 has been established by spectroscopy analysis, including UV, FT-IR, HRMS, 1H and 13C NMR spectroscopy. Based on the in silico studies, this compound showed a good potential as an inhibitor for dengue virus type 2 (DEN2) NS2B/NS3 serine protease and can be used as a reference in the next design of an antidengue virus. View Full-Text
Keywords: fluorinated pyrazolines; in silico study; microwave irradiation; one-pot three-component reaction; DEN2 NS2B/NS3 protease fluorinated pyrazolines; in silico study; microwave irradiation; one-pot three-component reaction; DEN2 NS2B/NS3 protease
MDPI and ACS Style

Zamri, A.; Teruna, H.Y.; Wulansari, S.; Herfindo, N.; Frimayanti, N.; Ikhtiarudin, I. 3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole. Molbank 2019, 2019, M1088.

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