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Volume 2019
Issue 4
10.3390/M1088
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Open AccessShort Note

3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

by
Adel Zamri
1,
Hilwan Y. Teruna
1,
Sri Wulansari
1,
Noval Herfindo
1,
Neni Frimayanti
2 and
Ihsan Ikhtiarudin
2,*
1
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Jalan H.R. Subrantas KM. 12.5, Pekanbaru 28293, Indonesia
2
Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Jalan Kamboja, Pekanbaru 28293, Indonesia
*
Author to whom correspondence should be addressed.
Molbank 2019, 2019(4), M1088; https://doi.org/10.3390/M1088
Received: 9 October 2019 / Revised: 5 November 2019 / Accepted: 8 November 2019 / Published: 12 November 2019
(This article belongs to the Section Organic Synthesis)
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Abstract

A new analogue of fluorinated pyrazoline (compound 1) has been synthesized via one-pot three-component reaction in a sealed-vessel reactor, Monowave 50. The structure of compound 1 has been established by spectroscopy analysis, including UV, FT-IR, HRMS, 1H and 13C NMR spectroscopy. Based on the in silico studies, this compound showed a good potential as an inhibitor for dengue virus type 2 (DEN2) NS2B/NS3 serine protease and can be used as a reference in the next design of an antidengue virus. View Full-Text
Keywords: fluorinated pyrazolines; in silico study; sealed-vessel reactor; Monowave 50; one-pot three-component reaction; DEN2 NS2B/NS3 protease fluorinated pyrazolines; in silico study; sealed-vessel reactor; Monowave 50; one-pot three-component reaction; DEN2 NS2B/NS3 protease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Zamri, A.; Teruna, H.Y.; Wulansari, S.; Herfindo, N.; Frimayanti, N.; Ikhtiarudin, I. 3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole. Molbank 2019, 2019, M1088. https://doi.org/10.3390/M1088

AMA Style

Zamri A, Teruna HY, Wulansari S, Herfindo N, Frimayanti N, Ikhtiarudin I. 3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole. Molbank. 2019; 2019(4):M1088. https://doi.org/10.3390/M1088

Chicago/Turabian Style

Zamri, Adel; Teruna, Hilwan Y.; Wulansari, Sri; Herfindo, Noval; Frimayanti, Neni; Ikhtiarudin, Ihsan. 2019. "3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole" Molbank 2019, no. 4: M1088. https://doi.org/10.3390/M1088

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