2,6-Bis[4-(4-butylphenyl)-1H-1,2,3-triazol-1-yl]-9-dodecyl-9H-purine

Round 1

Reviewer 1 Report

Authors demonstrated the Cu-catalyzed click reaction between 2,6-diazido-9-dodecyl-9H-purine and 4-n-butyl(phenylacetylene) for the synthesis of 2,6,9-trisubstituted purine derivative. The title compound carefully characterized and the NMR spectrum are pretty clean. However, the manuscript just described a common synthesis, and the yield is kind of low for such a robust reaction.

Reviewer 2 Report

The authors describe in this manuscript the preparation, and characterization of a previously unreported bis-triazolyl purine. The compound reported in this Note, has been rigorously described, and according to the Aims and Scope of the journal I recommend publication of the manuscript.

Minor,

Page 1, line 27,    replaced the monosaccharide

Reviewer 3 Report

The paper by Novosjolova and coworkers describes an efficient synthesis of a bis-(aryltriazolyl)-substituted purine derivative by copper-catalysed alkyne-azide cycloaddition. The prepared compound is a potentially very useful building block in the synthetic chemistry of purine analogues, which are particularly relevant in medicinal chemistry. The synthetic pathway is thoroughly described, and the target compound has been fully characterized. This is some sound work and I recommend its publication in Molbank, with the only minor point of criticism that the manuscript might benefit from another round of language polishing.