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Molbank 2019, 2019(1), M1046; https://doi.org/10.3390/M1046

(R,S)-5-(4-Chlorophenyl)-3-{(E)-2-[(R,S)-2,6,6-trimethylcyclohex-2-en-1-yl]vinyl}-4,5-dihydro-1H-pyrazole-1-carboximidamide Hydrochloride

Grupo de Pesquisa em Síntese e Caracterização Molecular, Faculdade de Ciências Exatas e Tecnologia, Universidade Federal da Grande Dourados, Rod. Dourados-Itahum, km 12, Dourados-MS 79804-970, Brazil
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Received: 4 January 2019 / Revised: 5 February 2019 / Accepted: 7 February 2019 / Published: 14 February 2019
(This article belongs to the Section Organic Synthesis)
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Abstract

Pyrazoline and amidine motifs are important in medicinal chemistry due to their broad spectrum of bioactivities. This work’s goal was to synthesize a new hybrid amidino pyrazoline from terpenyl chalcone. The chosen method consists of making the terpenyl chalcone react with aminoguanidine hydrochloride in the presence of potassium hydroxide using ethanol as solvent. The reaction was carried out under ultrasonic irradiation. The resulting terpenyl amidino pyrazoline was isolated after separation in a silica-gel chromatographic column in 86% of yield. The product structure was confirmed by the analysis of the high resolution mass, 1H and 13C-NMR spectra. The data was consistent with the expected structure. In summary, the method was efficient for the synthesis of a new hybrid terpenyl amidino pyrazolines under sonochemical conditions. View Full-Text
Keywords: cyclocondensation reaction; amidino pyrazoline; terpenyl pyrazoline; ultrasound cyclocondensation reaction; amidino pyrazoline; terpenyl pyrazoline; ultrasound
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Carvalho, M.C.; Pizzuti, L. (R,S)-5-(4-Chlorophenyl)-3-{(E)-2-[(R,S)-2,6,6-trimethylcyclohex-2-en-1-yl]vinyl}-4,5-dihydro-1H-pyrazole-1-carboximidamide Hydrochloride. Molbank 2019, 2019, M1046.

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