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Synthesis of 4-(2H-[1,2,4]-Triazol-5-ylsulfanyl)-1,2-dihydropyrazol-3-one via Ring-Switching Hydrazinolysis of 5-Ethoxymethylidenethiazolo [3,2-b][1,2,4]triazol-6-one
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Laboratoire ARNA, INSERM U1212 / UMR CNRS 5320, UFR des Sciences Pharmaceutiques, Univ. Bordeaux, 146 rue Léo Saignat, CEDEX, F-33076 Bordeaux, France
Cellules souches hématopoïétiques normales et leucémiques, INSERM U1035, UFR des Sciences Pharmaceutiques, Univ. Bordeaux, CEDEX, F-33076 Bordeaux, France
Author to whom correspondence should be addressed.
Molbank 2018, 2018(4), M1023;
Received: 25 September 2018 / Revised: 1 October 2018 / Accepted: 2 October 2018 / Published: 4 October 2018
(This article belongs to the Section Organic Synthesis)
The 1-methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole compound has been successfully synthesized via a multistep pathway starting from 2-phenylindole. Structure characterization of this new indole derivative was done by FTIR, 1H-NMR, 13C-NMR, and HRMS spectral analysis. The title compound showed high cytotoxic potential against five leukemia cell lines (K562, HL60, U937, U266, and Jurkat cell lines). View Full-Text
Keywords: indole derivative; leukemia; antiproliferative activity indole derivative; leukemia; antiproliferative activity
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Guillon, J.; Savrimoutou, S.; Rubio, S.; Desplat, V. 1-Methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole. Molbank 2018, 2018, M1023.

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