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Molbank 2018, 2018(4), M1023; https://doi.org/10.3390/M1023

1-Methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole

1
Laboratoire ARNA, INSERM U1212 / UMR CNRS 5320, UFR des Sciences Pharmaceutiques, Univ. Bordeaux, 146 rue Léo Saignat, CEDEX, F-33076 Bordeaux, France
2
Cellules souches hématopoïétiques normales et leucémiques, INSERM U1035, UFR des Sciences Pharmaceutiques, Univ. Bordeaux, CEDEX, F-33076 Bordeaux, France
*
Author to whom correspondence should be addressed.
Received: 25 September 2018 / Revised: 1 October 2018 / Accepted: 2 October 2018 / Published: 4 October 2018
(This article belongs to the Section Organic Synthesis)
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Abstract

The 1-methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole compound has been successfully synthesized via a multistep pathway starting from 2-phenylindole. Structure characterization of this new indole derivative was done by FTIR, 1H-NMR, 13C-NMR, and HRMS spectral analysis. The title compound showed high cytotoxic potential against five leukemia cell lines (K562, HL60, U937, U266, and Jurkat cell lines). View Full-Text
Keywords: indole derivative; leukemia; antiproliferative activity indole derivative; leukemia; antiproliferative activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Guillon, J.; Savrimoutou, S.; Rubio, S.; Desplat, V. 1-Methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole. Molbank 2018, 2018, M1023.

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