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1-(4-Hexylbenzoyl)-3-methylthiourea

1
Department of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Bakti Tunas Husada, Jl. Cilolohan No. 36, Tasikmalaya 46115, Indonesia
2
Scientific Consortium for Drug Discovery and Development, Faculty of Pharmacy, Universitas Padjadjaran, Bandung 45363, Indonesia
3
Department of Pharmacy, Universitas Perjuangan, Jl. Pembela Tanah Air 177, Tasikmalaya 46115, Indonesia
4
Faculty of Pharmacy, Airlangga University, Jl. Darmawangsa Dalam 4-6, Surabaya 60286, Indonesia
*
Author to whom correspondence should be addressed.
Molbank 2018, 2018(3), M1005; https://doi.org/10.3390/M1005
Received: 12 June 2018 / Revised: 5 July 2018 / Accepted: 6 July 2018 / Published: 9 July 2018
(This article belongs to the Section Organic Synthesis)
The 1-(4-hexylbenzoyl)-3-methylthiourea compound has been successfully synthesized by reacting 4-hexylbenzoyl chloride and 1-methylthiourea via the reflux method using a triethylamine catalyst. The 1-(4-hexylbenzoyl)-3-methylthiourea compound was identified by UV-visible, FT-IR, 13C/1H-NMR and Mass spectrophotometry. From the activity test on four cancer cell lines (HeLa, T47D, WiDr and MCF7 cell), it could be seen that it had better activity on four cancer cells than the control, hydroxyurea. View Full-Text
Keywords: acylation reaction; cancer; spectrophotometry; thiourea acylation reaction; cancer; spectrophotometry; thiourea
MDPI and ACS Style

Ruswanto, R.; Mardianingrum, R.; Lestari, T.; Nofianti, T.; Siswandono, S. 1-(4-Hexylbenzoyl)-3-methylthiourea. Molbank 2018, 2018, M1005.

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