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(E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acrylicc Acid

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
SAIDA FDS INC., 143-10 Isshiki, Yaizu, Shizuoka 425-0054, Japan
Author to whom correspondence should be addressed.
Molbank 2018, 2018(2), M996;
Received: 1 May 2018 / Revised: 8 May 2018 / Accepted: 9 May 2018 / Published: 12 May 2018
(This article belongs to the Section Organic Synthesis)
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(E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acetic acid is one of the useful components of liquid crystal materials which can be produced through Williamson ether synthesis by synthesizing 4-hydroxy-cinnamic acid and 5-bromo-1-pentene. Although Williamson ether synthesis is generally slow under conventional external heating conditions, microwave irradiation was effective for significant acceleration of the etherification. Furthermore, we demonstrated the rapid and continuous synthesis of (E)-3-[4-(pent-4-en-1-yloxy)phenyl]acetic acid, using a microwave-assisted flow reactor developed by us, in which the blockage by salt precipitation was suppressed by the continuous addition of an aqueous methanol solution after the reaction cavity. View Full-Text
Keywords: aryl alkyl ether; Williamson ether synthesis; microwave; flow chemistry aryl alkyl ether; Williamson ether synthesis; microwave; flow chemistry

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Egami, H.; Sawairi, T.; Tamaoki, S.; Ohneda, N.; Okamoto, T.; Odajima, H.; Hamashima, Y. (E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acrylicc Acid. Molbank 2018, 2018, M996.

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