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1-[5-(4-Ethoxyphenyl)-3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one

1
Department of Studies in Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India
2
Department of Industrial Chemistry, Mangalore University, Mangalagangothri-574199, Karnataka, India
*
Author to whom correspondence should be addressed.
Molbank 2018, 2018(2), M1000; https://doi.org/10.3390/M1000
Received: 23 May 2018 / Revised: 14 June 2018 / Accepted: 17 June 2018 / Published: 19 June 2018
(This article belongs to the Section Organic Synthesis)
The cyclization reaction of 3-(4-ethoxyphenyl)-1-(naphthalen-1-yl)prop-2-en-1-one (1) using hydrazine hydrate in acetic acid medium culminates, resulting in the title compound 1-[5-(4-ethoxyphenyl)-3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one (2). The structure of the newly synthesized compound is determined by IR, 1H-NMR, 13C-NMR and mass spectral data. In order to evaluate the putative molecular interactions, the title compound (2) is docked against the active site of Cytochrome P450 14α-sterol demethylase (CYP51) from Mycobacterium tuberculosis. View Full-Text
Keywords: pyrazoline; cytochrome P450; molecular docking pyrazoline; cytochrome P450; molecular docking
MDPI and ACS Style

Karanth, S.; Narayana, B.; Avvadukkam, J.; Sarojini, B.K. 1-[5-(4-Ethoxyphenyl)-3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one. Molbank 2018, 2018, M1000.

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